The successful design and synthesis of a novel multifunctional platinum drug candidate with DNA binding, histone deacetylase inhibitory activity and enhanced selectivity for cancer cells are described
Cancer remains a major global health burden despite significant advances in treatmentregimens. Curre...
Developing safer and/ or more effective chemotherapeutics has been a long-standing challenge in the ...
The polypharmacology strategy of multi-targeting drugs acting on different biological pathways is ca...
The successful design and synthesis of a novel multifunctional platinum drug candidate with DNA bind...
There is increasing evidence that histone deacetylase (HDAC) inhibitors can (re)sensitize cancer cel...
Cancer, the second leading cause of death, is a disease that can initiate in almost any part of the ...
Constant development for new medications and therapies is required due to the advancement of tumors ...
Platinum-based anticancer drugs, such as cisplatin, carboplatin, and oxaliplatin, have been approved...
Selective inhibition of histone deacetylases (HDACs) is an important strategy in the field of antica...
The search for metallodrugs (Pt or non-Pt based) which (i) target cancer cells and/or (ii) have a di...
The successful design and synthesis of a novel Pt complex of the histone deacteylase inhibitor belin...
Epigenetic agents such as histone deacetylase (HDAC) inhibitors are widely investigated for use in c...
Epigenetic agents such as histone deacetylase (HDAC) inhibitors are widely investigated for use in c...
Given our interest in finding potential antitumor agents and in view of the multifactorial mechanist...
In this work, we report the multicomponent synthesis of a focused histone deacetylase (HDAC) inhibit...
Cancer remains a major global health burden despite significant advances in treatmentregimens. Curre...
Developing safer and/ or more effective chemotherapeutics has been a long-standing challenge in the ...
The polypharmacology strategy of multi-targeting drugs acting on different biological pathways is ca...
The successful design and synthesis of a novel multifunctional platinum drug candidate with DNA bind...
There is increasing evidence that histone deacetylase (HDAC) inhibitors can (re)sensitize cancer cel...
Cancer, the second leading cause of death, is a disease that can initiate in almost any part of the ...
Constant development for new medications and therapies is required due to the advancement of tumors ...
Platinum-based anticancer drugs, such as cisplatin, carboplatin, and oxaliplatin, have been approved...
Selective inhibition of histone deacetylases (HDACs) is an important strategy in the field of antica...
The search for metallodrugs (Pt or non-Pt based) which (i) target cancer cells and/or (ii) have a di...
The successful design and synthesis of a novel Pt complex of the histone deacteylase inhibitor belin...
Epigenetic agents such as histone deacetylase (HDAC) inhibitors are widely investigated for use in c...
Epigenetic agents such as histone deacetylase (HDAC) inhibitors are widely investigated for use in c...
Given our interest in finding potential antitumor agents and in view of the multifactorial mechanist...
In this work, we report the multicomponent synthesis of a focused histone deacetylase (HDAC) inhibit...
Cancer remains a major global health burden despite significant advances in treatmentregimens. Curre...
Developing safer and/ or more effective chemotherapeutics has been a long-standing challenge in the ...
The polypharmacology strategy of multi-targeting drugs acting on different biological pathways is ca...
DOI
Add to ORKG