OBJECTIVES: To evaluate synovial tissue and serum biomarkers of disease activity, therapeutic response and radiographic progression during biological therapy for rheumatoid arthritis (RA). METHODS: Patients with active RA entered a randomised study of anakinra 100 mg/day, administered as monotherapy or in combination with pegsunercept 800 microg/kg twice a week. Arthroscopic synovial tissue biopsies were obtained at baseline and two further time points. Following immunohistochemical staining, selected mediators of RA pathophysiology were quantified using digital image analysis. Selected mediators were also measured in the serum. RESULTS: Twenty-two patients were randomly assigned: 11 received monotherapy and 11 combination therapy. American...
Objectives: To assess whether the histopathological features of the synovium before starting treatme...
Objectives: To assess whether the histopathological features of the synovium before starting treatme...
Objectives: To determine the impact on synovial histopathology of changes in clinical disease activi...
Objectives. To compare immunohistochemical scoring with clinical scoring and radiology for the asses...
OBJECTIVES: To investigate the effect of prolonged neutralisation of tumour necrosis factor alpha (T...
Objectives: To investigate the effect of prolonged neutralisation of tumour necrosis factor alpha (T...
Objective: To evaluate the relationship between disease activity and radiographic progression in rhe...
With the development of increasing numbers of potential therapeutic agents in inflammatory disease c...
<div><p>Introduction</p><p>The need for biomarkers which can predict disease course and treatment re...
The need for biomarkers which can predict disease course and treatment response in rheumatoid arthri...
Objective: To determine whether the heterogeneous clinical response to tumour necrosis factor (TNF)a...
Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial ...
Aim: The laboratory findings are non-specific in Rheumatoid arthritis (RA). We have based our study ...
Objectives: To determine the impact on synovial histopathology of changes in clinical disease activi...
Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial ...
Objectives: To assess whether the histopathological features of the synovium before starting treatme...
Objectives: To assess whether the histopathological features of the synovium before starting treatme...
Objectives: To determine the impact on synovial histopathology of changes in clinical disease activi...
Objectives. To compare immunohistochemical scoring with clinical scoring and radiology for the asses...
OBJECTIVES: To investigate the effect of prolonged neutralisation of tumour necrosis factor alpha (T...
Objectives: To investigate the effect of prolonged neutralisation of tumour necrosis factor alpha (T...
Objective: To evaluate the relationship between disease activity and radiographic progression in rhe...
With the development of increasing numbers of potential therapeutic agents in inflammatory disease c...
<div><p>Introduction</p><p>The need for biomarkers which can predict disease course and treatment re...
The need for biomarkers which can predict disease course and treatment response in rheumatoid arthri...
Objective: To determine whether the heterogeneous clinical response to tumour necrosis factor (TNF)a...
Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial ...
Aim: The laboratory findings are non-specific in Rheumatoid arthritis (RA). We have based our study ...
Objectives: To determine the impact on synovial histopathology of changes in clinical disease activi...
Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial ...
Objectives: To assess whether the histopathological features of the synovium before starting treatme...
Objectives: To assess whether the histopathological features of the synovium before starting treatme...
Objectives: To determine the impact on synovial histopathology of changes in clinical disease activi...