Autotaxin (ATX) is a lysophospholipase D involved in synthesis of lysophosphatidic acid (LPA). ATX is secreted by adipocytes and is associated with adipogenesis and obesity-associated diabetes. Here we have studied the mechanisms involved in biosynthesis and secretion of ATX by mouse 3T3-F442A adipocytes. We found that inhibition of N-glycosylation with tunicamycin or by double point deletion of the amino-acids N53 and N410 of ATX inhibit its secretion. In addition, N-glycosidase treatment and point deletion of the amino-acid N410 inhibits the lysophospholipase D activity of ATX. Analysis of the amino-acid sequence of mouse ATX shows the presence of a N-terminal signal peptide. Treatment with the signal peptidase inhibitor globomycin inhibi...
Autotaxin (ATX) is a secreted enzyme that generates the bioactive lipid lysophosphatidic acid (LPA)....
Autotaxin (ATX) is a secreted enzyme that generates the bioactive lipid lysophosphatidic acid (LPA)....
The aim of the present work was to depict the metabolic pathways involved in extracellular productio...
Autotaxin (ATX) is a lysophospholipase D involved in synthesis of lysophosphatidic acid (LPA). ATX i...
Our group has recently demonstrated (Gesta, S., Simon, M., Rey, A., Sibrac, D., Girard, A., Lafontan...
International audienceIn obesity, adipocyte hypertrophy is often associated with recrutement of new ...
International audienceAutotaxin (ATX) is a secreted lysophospholipase D that generates the lipid med...
AIMS/HYPOTHESIS: Autotaxin is a lysophospholipase D that is secreted by adipocytes and whose express...
Autotaxin (ATX) is a secreted enzyme that generates the bioactive lipid lysophosphatidic acid (LPA)....
International audienceAutotaxin (ATX) is a lysophospholipase D involved in synthesis of a bioactive ...
Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activate
Autotaxin (ATX) is a secreted enzyme that generates the bioactive lipid lysophosphatidic acid (LPA)....
Autotaxin (ATX) is a secreted enzyme that generates the bioactive lipid lysophosphatidic acid (LPA)....
The aim of the present work was to depict the metabolic pathways involved in extracellular productio...
Autotaxin (ATX) is a lysophospholipase D involved in synthesis of lysophosphatidic acid (LPA). ATX i...
Our group has recently demonstrated (Gesta, S., Simon, M., Rey, A., Sibrac, D., Girard, A., Lafontan...
International audienceIn obesity, adipocyte hypertrophy is often associated with recrutement of new ...
International audienceAutotaxin (ATX) is a secreted lysophospholipase D that generates the lipid med...
AIMS/HYPOTHESIS: Autotaxin is a lysophospholipase D that is secreted by adipocytes and whose express...
Autotaxin (ATX) is a secreted enzyme that generates the bioactive lipid lysophosphatidic acid (LPA)....
International audienceAutotaxin (ATX) is a lysophospholipase D involved in synthesis of a bioactive ...
Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activate
Autotaxin (ATX) is a secreted enzyme that generates the bioactive lipid lysophosphatidic acid (LPA)....
Autotaxin (ATX) is a secreted enzyme that generates the bioactive lipid lysophosphatidic acid (LPA)....
The aim of the present work was to depict the metabolic pathways involved in extracellular productio...