Basic fibroblast growth factor (bFGF) exerts a mitogenic effect on cortical neuroblasts, whereas neurotrophin 3 (NT3) promotes differentiation in these cells. Here we provide evidence that both the mitogenic effect of bFGF and the differentiation-promoting effect of NT3 are linked with modifications of cell cycle kinetics in mouse cortical precursor cells. We adapted an in vitro assay, which makes it possible to evaluate (1) the speed of progression of the cortical precursors through the cell cycle, (2) the duration of individual phases of the cell cycle, (3) the proportion of proliferative versus differentiative divisions, and (4) the influence on neuroglial differentiation. Contrary to what has been claimed previously, bFGF promotes proli...
Despite heterogeneity across the six layers of the mammalian cortex, all excitatory neurons are gene...
Background: Growth, differentiation and regional specification of telencephalic domains, such as the...
presented by LUIZ R. TRAVASSOS Cell therapy for neurological disorders has advanced, and neural prec...
Basic fibroblast growth factor (bFGF) exerts a mitogenic effect on cortical neuroblasts, whereas neu...
Basic fibroblast growth factor (bFGF) exerts a mitogenic effect on cortical neuroblasts, whereas neu...
AbstractTo identify molecules that regulate the transition of dividing neuroblasts to terminally dif...
Contrasting effects of basic fibroblast growth factor and neurotrophin 3 on cell cycle kinetics of m...
Identifying the mechanisms that regulate neural precursor cell (NPC) proliferation and differentiati...
Summary: The balance between factors leading to proliferation and differentiation of cortical neural...
We have previously shown that mice carrying the K644E kinase domain mutation in fibroblast growth fa...
SummaryRadial glia (RG), the progenitors of cortical neurons and basal progenitors (BPs), differenti...
AbstractRestrictions in neuronal fate occur during the transition from a multipotential to a postmit...
peer reviewedThe balance between factors leading to proliferation and differentiation of cortical ne...
Neurogenesis in the developing cerebral cortex of mice occurs in the dorsal telencephalon between em...
<p>Embryonic OBSCs (<b>A–D</b>) and adult OBSCs (prepared from 7- and 15-month old mice; <b>E–H</b>)...
Despite heterogeneity across the six layers of the mammalian cortex, all excitatory neurons are gene...
Background: Growth, differentiation and regional specification of telencephalic domains, such as the...
presented by LUIZ R. TRAVASSOS Cell therapy for neurological disorders has advanced, and neural prec...
Basic fibroblast growth factor (bFGF) exerts a mitogenic effect on cortical neuroblasts, whereas neu...
Basic fibroblast growth factor (bFGF) exerts a mitogenic effect on cortical neuroblasts, whereas neu...
AbstractTo identify molecules that regulate the transition of dividing neuroblasts to terminally dif...
Contrasting effects of basic fibroblast growth factor and neurotrophin 3 on cell cycle kinetics of m...
Identifying the mechanisms that regulate neural precursor cell (NPC) proliferation and differentiati...
Summary: The balance between factors leading to proliferation and differentiation of cortical neural...
We have previously shown that mice carrying the K644E kinase domain mutation in fibroblast growth fa...
SummaryRadial glia (RG), the progenitors of cortical neurons and basal progenitors (BPs), differenti...
AbstractRestrictions in neuronal fate occur during the transition from a multipotential to a postmit...
peer reviewedThe balance between factors leading to proliferation and differentiation of cortical ne...
Neurogenesis in the developing cerebral cortex of mice occurs in the dorsal telencephalon between em...
<p>Embryonic OBSCs (<b>A–D</b>) and adult OBSCs (prepared from 7- and 15-month old mice; <b>E–H</b>)...
Despite heterogeneity across the six layers of the mammalian cortex, all excitatory neurons are gene...
Background: Growth, differentiation and regional specification of telencephalic domains, such as the...
presented by LUIZ R. TRAVASSOS Cell therapy for neurological disorders has advanced, and neural prec...