International audienceEstrogen represents an important factor for the development and function of the nigrostriatal dopamine system. Estrogen also controls sex-specific differentiation and activity of the nigrostriatal dopaminergic system. We used an estrogen receptor-alpha knockout (-/-) model (ERKO) to study the influence of this particular receptor subtype on the regulation of functional characteristics of the male and female nigrostriatal dopamine system. On the striatal level, we found a sex-specific regulation of dopamine D1 receptors (D1) and dopamine receptor-interacting protein 78 (Drip78). In female (-/-) mice D1 receptor expression levels were increased compared to wild type (wt) animals, whereas in male (-/-) mice Drip78 mRNA le...
Aromatase catalyses the last step of oestrogen synthesis. There is growing evidence that local oestr...
The aim of this study was to investigate further the hormone-dependent processes underlying sex diff...
Steroid receptor activation in the developing brain influences a variety of cellular processes that ...
International audienceEstrogen represents an important factor for the development and function of th...
AbstractOestradiol establishes neural sex differences in many vertebrates1–3 and modulates mood, beh...
Estrogen synthesized in situ in the CNS by the enzyme aromatase plays an important role during brain...
Treatment with resveratrol (RSV) has been shown to protect vulnerable neurons after various brain in...
Gender difference in Parkinson's disease (PD) suggests that female sex steroids may promote dopamine...
International audienceAbstract Estrogen receptor (ER) α is involved in several estrogen-modulated ne...
Neuroprotection by 17β-estradiol and an estrogen receptor (ER) agonist against 1-methyl-4-phenyl-1,2...
Gender difference in Parkinson’s disease (PD) suggests that female sex steroids may promote dopamine...
<p>Dopamine regulates movement, cognition and the rewarding effects of addictive drugs. Sex differen...
Epidemiological data suggest a sexual dimorphism in Parkinson disease (PD), with women showing lower...
Brain-Derived Neurotrophic Factor (BDNF) is considered one of the most influential neurotrophins in ...
<p>Sex differences in drug addiction are mediated in part by effects of the ovarian hormone estradio...
Aromatase catalyses the last step of oestrogen synthesis. There is growing evidence that local oestr...
The aim of this study was to investigate further the hormone-dependent processes underlying sex diff...
Steroid receptor activation in the developing brain influences a variety of cellular processes that ...
International audienceEstrogen represents an important factor for the development and function of th...
AbstractOestradiol establishes neural sex differences in many vertebrates1–3 and modulates mood, beh...
Estrogen synthesized in situ in the CNS by the enzyme aromatase plays an important role during brain...
Treatment with resveratrol (RSV) has been shown to protect vulnerable neurons after various brain in...
Gender difference in Parkinson's disease (PD) suggests that female sex steroids may promote dopamine...
International audienceAbstract Estrogen receptor (ER) α is involved in several estrogen-modulated ne...
Neuroprotection by 17β-estradiol and an estrogen receptor (ER) agonist against 1-methyl-4-phenyl-1,2...
Gender difference in Parkinson’s disease (PD) suggests that female sex steroids may promote dopamine...
<p>Dopamine regulates movement, cognition and the rewarding effects of addictive drugs. Sex differen...
Epidemiological data suggest a sexual dimorphism in Parkinson disease (PD), with women showing lower...
Brain-Derived Neurotrophic Factor (BDNF) is considered one of the most influential neurotrophins in ...
<p>Sex differences in drug addiction are mediated in part by effects of the ovarian hormone estradio...
Aromatase catalyses the last step of oestrogen synthesis. There is growing evidence that local oestr...
The aim of this study was to investigate further the hormone-dependent processes underlying sex diff...
Steroid receptor activation in the developing brain influences a variety of cellular processes that ...