International audienceIn LQT3 patients, SCN5A mutations induce ultraslow inactivation of a small fraction of the hNav1.5 current, i.e. persistent Na+ current (I pNa). We explored the time course of effects of such a change on the intracellular ionic homeostasis in a model of guinea-pig cardiac ventricular cell [Pasek,M., Simurda,J., Orchard,C.H., Christe,G., 2007b. A model of the guinea-pig ventricular cardiomyocyte incorporating a transverse–axial tubular system. Prog. Biophys. Mol. Biol., this issue]. Sudden addition of IpNa prevented action potential (AP) repolarization when its conductance (gpNa) exceeded 0.12% of the maximal conductance of fast INa (gNa). With gpNa at 0.1% gNa, the AP duration at 90% repolarization (APD90) was initiall...
Long QT syndrome (LQTS) and Brugada syndrome (BrS) are inherited diseases predisposing to ventricu...
Long QT syndrome (LQTS) type 3 is characterized by prolonged ventricular repolarization due to persi...
Long QT syndrome type 3 (LQT3) has been traced to mutations of the cardiac Na(+) channel (Na(v)1.5) ...
International audienceIn LQT3 patients, SCN5A mutations induce ultraslow inactivation of a small fra...
In LQT3 patients, SCN5A mutations were found that lead to a small fraction of persistent hNav1.5 cur...
Long-QT3 syndrome (LQT3) is linked to cardiac sodium channel gene (SCN5A) mutations. In this study, ...
Background: Long QT syndrome mutations in the SCN5A gene are associated with an enhanced late sodium...
BACKGROUND: D1790G, a mutation of SCN5A, the gene that encodes the human Na(+) channel alpha-subunit...
Brugada syndrome (BrS) is an inherited cardiac arrhythmia commonly associated with SCN5A mutations, ...
The slowly inactivating or late Na+ current, INa-L, can contribute to the initiation of both atrial ...
The Long QT3 syndrome is associated with mutations in the cardiac sodium channel gene SCN5A. Objecti...
Objective: Congenital long QT syndrome type 3 (LQT3) is an inherited cardiac arrhythmia disorder due...
Mutations in the gene (SCN5A) encoding the alpha-subunit of the cardiac Na+ channel cause congenital...
Long QT syndrome (LQTS) and Brugada syndrome (BrS) are inherited diseases predisposing to ventricu...
Long QT syndrome (LQTS) type 3 is characterized by prolonged ventricular repolarization due to persi...
Long QT syndrome type 3 (LQT3) has been traced to mutations of the cardiac Na(+) channel (Na(v)1.5) ...
International audienceIn LQT3 patients, SCN5A mutations induce ultraslow inactivation of a small fra...
In LQT3 patients, SCN5A mutations were found that lead to a small fraction of persistent hNav1.5 cur...
Long-QT3 syndrome (LQT3) is linked to cardiac sodium channel gene (SCN5A) mutations. In this study, ...
Background: Long QT syndrome mutations in the SCN5A gene are associated with an enhanced late sodium...
BACKGROUND: D1790G, a mutation of SCN5A, the gene that encodes the human Na(+) channel alpha-subunit...
Brugada syndrome (BrS) is an inherited cardiac arrhythmia commonly associated with SCN5A mutations, ...
The slowly inactivating or late Na+ current, INa-L, can contribute to the initiation of both atrial ...
The Long QT3 syndrome is associated with mutations in the cardiac sodium channel gene SCN5A. Objecti...
Objective: Congenital long QT syndrome type 3 (LQT3) is an inherited cardiac arrhythmia disorder due...
Mutations in the gene (SCN5A) encoding the alpha-subunit of the cardiac Na+ channel cause congenital...
Long QT syndrome (LQTS) and Brugada syndrome (BrS) are inherited diseases predisposing to ventricu...
Long QT syndrome (LQTS) type 3 is characterized by prolonged ventricular repolarization due to persi...
Long QT syndrome type 3 (LQT3) has been traced to mutations of the cardiac Na(+) channel (Na(v)1.5) ...