International audiencePURPOSE: To assess the association between physical job demands (PJD) and physical/cognitive functional limitations, and the role of adverse health behaviours, obesity, and socio-demographic factors as confounders of those associations. METHODS: The sample included 3,368 active subjects aged 18-64 years, randomly selected from North-eastern France. Subjects completed a post-mailed questionnaire. PJD score was defined as the product of years of employment with the cumulative number of a wide range of high job demands. Data were analysed through the logistic regression models. RESULTS: The physical and cognitive functional limitations affected 16.9 and 28.6% of subjects, respectively. A strong relationship was found betw...