Effects of HIV protease inhibitors on progression of monocrotaline- and hypoxia-induced pulmonary hypertension in rats.

Hepatocyte growth factor suppresses vascular medial hyperplasia and matrix accumulation in advanced pulmonary hypertension of rats. Circulation

Masamichi Ono
Norihida Fukushima
Toshikazu Nakamura Phd Hikaru Matsuda

October 2016

Background—Pulmonary hypertension (PH) is a progressive disease characterized by raised pulmonary va...

Phosphodiesterase-5 Inhibition Alleviates Pulmonary Hypertension and Basal Lamina Thickening in Rats Challenged by Chronic Hypoxia

Coline Nydegger
Carla Martinelli
Fabiano Di Marco
Fabiano Di Marco
Gaetano Bulfamante
Gaetano Bulfamante
Ludwig von Segesser
Piergiorgio Tozzi
Michele Samaja
Giuseppina Milano

March 2018

Background: Hypoxia represents both an outcome of cardiopulmonary diseases and a trigger for severe ...

Phosphodiesterase type 5 as a target for the treatment of hypoxia-induces pulmonary hypertension. Circulation 107: 3230–3235

A. Sebkhi
Phd Julian
W. Strange
Mb Steven
C. Phillips
John Wharton
Phd Martin
R. Wilkins

January 2003

Background—Phosphodiesterase type 5 (PDE5) is a novel therapeutic target for the treatment of pulmon...

Effects of HIV protease inhibitors on progression of monocrotaline- and hypoxia-induced pulmonary hypertension in rats.

Gary-Bobo, Guillaume
Houssaini, Amal
Amsellem, Valerie
Rideau, Dominique
Pacaud, Pierre
Perrin, Aline
Brégeon, Jérémy
Marcos, Elisabeth
Dubois-Randé, Jean-Luc
Sitbon, Olivier
Savale, Laurent
Adnot, Serge

November 2010

International audienceThese results support an effect of HPIs on pulmonary vascular remodeling media...

Effects of HIV drug combinations on endothelin-1 and vascular cell proliferation

Hebert, Valeria Y
Crenshaw, Brian L
Romanoff, Rachelle L
Ekshyyan, Viktoriya P
Dugas, Tammy R

January 2004

Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature involvin...

Phosphodiesterase V Inhibitors Dilate the Pulmonary Artery of Monocrotaline-Induced Pulmonary Hypertensive Rats

Makita Tetsuji
Tsutsumi Yohsuke
Cho Sungsam
Shibata Osamu
Sumikawa Koji

March 2005

Treatment of pulmonary hypertension has not yet been established and effective drug therapies are re...

Cardio-Metabolic Effects of HIV Protease Inhibitors (Lopinavir/Ritonavir)

Kathleenm. S. E Reyskens
Tarryn-lee Fisher
Jonathan C. Schisler
Wendi G. O’connor
Arlin B. Rogers
Monte S. Willis
Cynthia Planesse
Florence Boyer
Emmanuel Bourdon
M. Faadiel Essop

August 2016

Although antiretroviral treatment decreases HIV-AIDS morbidity/mortality, long-term side effects may...

Pulmonary Hypertension Remodels the Genomic Fabrics of Major Functional Pathways

Mathew, Rajamma
Huang, Jing
Iacobas, Sanda
Iacobas, Dumitru A

January 2020

Pulmonary hypertension (PH) is a serious disorder with high morbidity and mortality rate. We analyze...

3-Hydroxy-3-Methylglutaryl-CoA Reductase Inhibitors and Phosphodiesterase Type V Inhibitors Attenuate Right Ventricular Pressure and Remodeling in a Rat Model of Pulmonary Hypertension

Mitsutoshi Satoh
Akira Satoh

January 2015

ABSTRACT- Purpose. We examined the inhibitory effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reduct...

Therapeutic efficacy of valproic acid in a combined monocrotaline and chronic hypoxia rat model of severe pulmonary hypertension.

Beidi Lan
Emiko Hayama
Nanako Kawaguchi
Yoshiyuki Furutani
Toshio Nakanishi

BACKGROUND:Pulmonary hypertension (PH) is a serious disease with poor prognosis. Reports show that c...

Impact of human immunodeficiency virus on pulmonary vascular disease

Kumar, Ashok
Mahajan, Aatish
Salazar, Ethan A.
Pruitt, Kevin
Guzman, Christian Arce
Clauss, Matthias A.
Almodovar, Sharilyn
Dhillon, Navneet K.

June 2021

With the advent of anti-retroviral therapy, non-AIDS-related comorbidities have increased in people ...

Inhibition of Anaplerosis Attenuated Vascular Proliferation in Pulmonary Arterial Hypertension

Valuparampil Varghese, Mathews
James, Joel
Eccles, Cody A
Niihori, Maki
Rafikova, Olga
Rafikov, Ruslan

February 2020

Vascular remodeling is considered a key event in the pathogenesis of pulmonary arterial hypertension...

HIV transgene expression impairs K+ channel function in the pulmonary vasculature

Mondejar-Parreño, G
Morales-Cano, D
Barreira, B
Callejo, M
Ruiz-Cabello, J
Moreno, L
Esquivel-Ruiz, S
Mathie, A
Butrous, G
Perez-Vizcaino, F
Cogolludo, A.

October 2018

Human immunodeficiency virus (HIV) infection is an established risk factor for pulmonary arterial hy...

Inhibition of Shp2 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats

Yusheng Cheng
Min Yu
Jian Xu
Mengyu He
Hong Wang
Hui Kong
Weiping Xie

August 2018

Abstract Background Src homology 2 containing protein tyrosine phosphatase (PTP) 2 (Shp2) is a typic...

Arterial Morphology Responds Differently to Captopril then N-Acetylcysteine in a Monocrotaline Rat Model of Pulmonary Hypertension

Molthen, Robert C.
Wu, QingPing
Baumgardt, Shelley
Kohlhepp, Laura
Shingrani, Rahul
Krenz, Gary S.

March 2010

Pulmonary hypertension (PH) is an incurable condition inevitably resulting in death because of incre...

Hepatocyte growth factor suppresses vascular medial hyperplasia and matrix accumulation in advanced pulmonary hypertension of rats. Circulation

Masamichi Ono
Norihida Fukushima
Toshikazu Nakamura Phd Hikaru Matsuda

October 2016

Background—Pulmonary hypertension (PH) is a progressive disease characterized by raised pulmonary va...

Phosphodiesterase-5 Inhibition Alleviates Pulmonary Hypertension and Basal Lamina Thickening in Rats Challenged by Chronic Hypoxia

Coline Nydegger
Carla Martinelli
Fabiano Di Marco
Fabiano Di Marco
Gaetano Bulfamante
Gaetano Bulfamante
Ludwig von Segesser
Piergiorgio Tozzi
Michele Samaja
Giuseppina Milano

March 2018

Background: Hypoxia represents both an outcome of cardiopulmonary diseases and a trigger for severe ...

Phosphodiesterase type 5 as a target for the treatment of hypoxia-induces pulmonary hypertension. Circulation 107: 3230–3235

A. Sebkhi
Phd Julian
W. Strange
Mb Steven
C. Phillips
John Wharton
Phd Martin
R. Wilkins

January 2003

Background—Phosphodiesterase type 5 (PDE5) is a novel therapeutic target for the treatment of pulmon...

Effects of HIV protease inhibitors on progression of monocrotaline- and hypoxia-induced pulmonary hypertension in rats.

Gary-Bobo, Guillaume
Houssaini, Amal
Amsellem, Valerie
Rideau, Dominique
Pacaud, Pierre
Perrin, Aline
Brégeon, Jérémy
Marcos, Elisabeth
Dubois-Randé, Jean-Luc
Sitbon, Olivier
Savale, Laurent
Adnot, Serge

November 2010

International audienceThese results support an effect of HPIs on pulmonary vascular remodeling media...

Effects of HIV drug combinations on endothelin-1 and vascular cell proliferation

Hebert, Valeria Y
Crenshaw, Brian L
Romanoff, Rachelle L
Ekshyyan, Viktoriya P
Dugas, Tammy R

January 2004

Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature involvin...

Phosphodiesterase V Inhibitors Dilate the Pulmonary Artery of Monocrotaline-Induced Pulmonary Hypertensive Rats

Makita Tetsuji
Tsutsumi Yohsuke
Cho Sungsam
Shibata Osamu
Sumikawa Koji

March 2005

Treatment of pulmonary hypertension has not yet been established and effective drug therapies are re...

Cardio-Metabolic Effects of HIV Protease Inhibitors (Lopinavir/Ritonavir)

Kathleenm. S. E Reyskens
Tarryn-lee Fisher
Jonathan C. Schisler
Wendi G. O’connor
Arlin B. Rogers
Monte S. Willis
Cynthia Planesse
Florence Boyer
Emmanuel Bourdon
M. Faadiel Essop

August 2016

Although antiretroviral treatment decreases HIV-AIDS morbidity/mortality, long-term side effects may...

Pulmonary Hypertension Remodels the Genomic Fabrics of Major Functional Pathways

Mathew, Rajamma
Huang, Jing
Iacobas, Sanda
Iacobas, Dumitru A

January 2020

Pulmonary hypertension (PH) is a serious disorder with high morbidity and mortality rate. We analyze...

3-Hydroxy-3-Methylglutaryl-CoA Reductase Inhibitors and Phosphodiesterase Type V Inhibitors Attenuate Right Ventricular Pressure and Remodeling in a Rat Model of Pulmonary Hypertension

Mitsutoshi Satoh
Akira Satoh

January 2015

ABSTRACT- Purpose. We examined the inhibitory effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reduct...

Therapeutic efficacy of valproic acid in a combined monocrotaline and chronic hypoxia rat model of severe pulmonary hypertension.

Beidi Lan
Emiko Hayama
Nanako Kawaguchi
Yoshiyuki Furutani
Toshio Nakanishi

BACKGROUND:Pulmonary hypertension (PH) is a serious disease with poor prognosis. Reports show that c...

Impact of human immunodeficiency virus on pulmonary vascular disease

Kumar, Ashok
Mahajan, Aatish
Salazar, Ethan A.
Pruitt, Kevin
Guzman, Christian Arce
Clauss, Matthias A.
Almodovar, Sharilyn
Dhillon, Navneet K.

June 2021

With the advent of anti-retroviral therapy, non-AIDS-related comorbidities have increased in people ...

Inhibition of Anaplerosis Attenuated Vascular Proliferation in Pulmonary Arterial Hypertension

Valuparampil Varghese, Mathews
James, Joel
Eccles, Cody A
Niihori, Maki
Rafikova, Olga
Rafikov, Ruslan

February 2020

Vascular remodeling is considered a key event in the pathogenesis of pulmonary arterial hypertension...

HIV transgene expression impairs K+ channel function in the pulmonary vasculature

Mondejar-Parreño, G
Morales-Cano, D
Barreira, B
Callejo, M
Ruiz-Cabello, J
Moreno, L
Esquivel-Ruiz, S
Mathie, A
Butrous, G
Perez-Vizcaino, F
Cogolludo, A.

October 2018

Human immunodeficiency virus (HIV) infection is an established risk factor for pulmonary arterial hy...

Inhibition of Shp2 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats

Yusheng Cheng
Min Yu
Jian Xu
Mengyu He
Hong Wang
Hui Kong
Weiping Xie

August 2018

Abstract Background Src homology 2 containing protein tyrosine phosphatase (PTP) 2 (Shp2) is a typic...

Arterial Morphology Responds Differently to Captopril then N-Acetylcysteine in a Monocrotaline Rat Model of Pulmonary Hypertension

Molthen, Robert C.
Wu, QingPing
Baumgardt, Shelley
Kohlhepp, Laura
Shingrani, Rahul
Krenz, Gary S.

March 2010

Pulmonary hypertension (PH) is an incurable condition inevitably resulting in death because of incre...

Hepatocyte growth factor suppresses vascular medial hyperplasia and matrix accumulation in advanced pulmonary hypertension of rats. Circulation

Masamichi Ono
Norihida Fukushima
Toshikazu Nakamura Phd Hikaru Matsuda

October 2016

Background—Pulmonary hypertension (PH) is a progressive disease characterized by raised pulmonary va...

Phosphodiesterase-5 Inhibition Alleviates Pulmonary Hypertension and Basal Lamina Thickening in Rats Challenged by Chronic Hypoxia

Coline Nydegger
Carla Martinelli
Fabiano Di Marco
Fabiano Di Marco
Gaetano Bulfamante
Gaetano Bulfamante
Ludwig von Segesser
Piergiorgio Tozzi
Michele Samaja
Giuseppina Milano

March 2018

Background: Hypoxia represents both an outcome of cardiopulmonary diseases and a trigger for severe ...

Phosphodiesterase type 5 as a target for the treatment of hypoxia-induces pulmonary hypertension. Circulation 107: 3230–3235

A. Sebkhi
Phd Julian
W. Strange
Mb Steven
C. Phillips
John Wharton
Phd Martin
R. Wilkins

January 2003

Background—Phosphodiesterase type 5 (PDE5) is a novel therapeutic target for the treatment of pulmon...

Effects of HIV protease inhibitors on progression of monocrotaline- and hypoxia-induced pulmonary hypertension in rats.

Abstract

Extracted data

Effects of HIV protease inhibitors on progression of monocrotaline- and hypoxia-induced pulmonary hypertension in rats.

Abstract

Extracted data

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