White matter lesions in FTLD: distinct phenotypes characterize GRN and C9ORF72 mutations

International audienceFrontotemporal lobar degeneration (FTLD) has ahigh frequency of genetic forms; the 2 most commonare GRN (progranulin) and C9ORF72 mutations.Recently, our group reported extensive white matter(WM) lesions in 4 patients with FTLD caused byGRN mutation, in the absence of noteworthy cardiovascularrisk factors,1 in line with other studies inGRN mutation carriers.2,3 Here we compared thecharacteristics of frontal WM lesions in patients withbehavioral variant of FTLD (bv-FTLD) caused byGRN and C9ORF72 mutations