International audienceDespite its negative regulatory role on tumor specific T cells, PD-1 is also a marker ofactivated tumor-infiltrating T cells. In cancer, PD-1 blockade partially reverses T celldysfunction allowing the amplification of tumor reactive T cells. Here we investigated therole of PD-1 signaling on effector/memory human T cells specific for shared melanomaantigens, derived from blood. We documented for the first time the existence of melanomaspecific T cell clones unable to express PD-1. This stable feature was due to the persistentmethylation of the PDCD1 promoter. PD-1pos counterparts, suggesting that high affinity specific T cell clones unable to express PD-1 are not or rarely present in peripheral blood, as they are probab...
Therapeutic antibodies targeting programmed cell death 1 (PD-1) activate tumor-specific immunity and...
Despite major progress in T lymphocyte analysis in melanoma patients, TCR repertoire selection and k...
International audienceBACKGROUND:Genome editing offers unique perspectives for optimizing the functi...
International audienceDespite its negative regulatory role on tumor specific T cells, PD-1 is also a...
BackgroundGenome editing offers unique perspectives for optimizing the functional properties of T ce...
Programmed death-1 (PD-1) is involved in T-cell tolerance to self-antigens. For some cancers, it has...
International audienceTherapeutic strategies using anti-PD-1-blocking antibodies reported unparallel...
UnrestrictedNegative costimulatory signaling mediated via cell surface Programmed Death-1 (PD-1) exp...
Bien qu’ayant bouleversé la prise en charge des patients atteints de mélanome, une large fraction de...
Abstract Monoclonal antibodies (abs) targeting the programmed cell death 1 (PD-1) immune checkpoint ...
PD-1 is expressed on exhausted T cells in cancer patients but its physiological role remains uncerta...
Therapies that target the programmed death-1 (PD-1) receptor have shown unprecedented rates of durab...
Tumor responses to programmed cell death protein 1 (PD-1) blockade therapy are mediated by T cells, ...
SummaryTherapeutic antibodies targeting programmed cell death 1 (PD-1) activate tumor-specific immun...
Therapeutic antibodies targeting programmed cell death 1 (PD-1) activate tumor-specific immunity and...
Therapeutic antibodies targeting programmed cell death 1 (PD-1) activate tumor-specific immunity and...
Despite major progress in T lymphocyte analysis in melanoma patients, TCR repertoire selection and k...
International audienceBACKGROUND:Genome editing offers unique perspectives for optimizing the functi...
International audienceDespite its negative regulatory role on tumor specific T cells, PD-1 is also a...
BackgroundGenome editing offers unique perspectives for optimizing the functional properties of T ce...
Programmed death-1 (PD-1) is involved in T-cell tolerance to self-antigens. For some cancers, it has...
International audienceTherapeutic strategies using anti-PD-1-blocking antibodies reported unparallel...
UnrestrictedNegative costimulatory signaling mediated via cell surface Programmed Death-1 (PD-1) exp...
Bien qu’ayant bouleversé la prise en charge des patients atteints de mélanome, une large fraction de...
Abstract Monoclonal antibodies (abs) targeting the programmed cell death 1 (PD-1) immune checkpoint ...
PD-1 is expressed on exhausted T cells in cancer patients but its physiological role remains uncerta...
Therapies that target the programmed death-1 (PD-1) receptor have shown unprecedented rates of durab...
Tumor responses to programmed cell death protein 1 (PD-1) blockade therapy are mediated by T cells, ...
SummaryTherapeutic antibodies targeting programmed cell death 1 (PD-1) activate tumor-specific immun...
Therapeutic antibodies targeting programmed cell death 1 (PD-1) activate tumor-specific immunity and...
Therapeutic antibodies targeting programmed cell death 1 (PD-1) activate tumor-specific immunity and...
Despite major progress in T lymphocyte analysis in melanoma patients, TCR repertoire selection and k...
International audienceBACKGROUND:Genome editing offers unique perspectives for optimizing the functi...