Insight into the copper-catalyzed borylation of strained alkenes

This document is the accepted manuscript version of a published work that appeared in final form in Synlett 2015; 26(04): 494-500, copyright © Georg Thieme Verlag Stuttgart · New York after peer review and technical editing by the publisher. To access the final online work see DOI: 10.1055/s-0034-1379882The copper-catalyzed hydro- and carboboration of strain alkenes is presented. The reaction is highly diastereoselective and affords boronic ester derivatives many of which are difficult to synthesize by known methods. Competition experiments with different alkenes show that high levels of chemoselectivity can be achieved. DFT calculations are in agreement with the observed chemoselectivityWe thank the European Research Council (ERC-337776) and MINECO (CTQ2012-35957 and CTQ2013-43698-P) for financial support. M. T. and S. D.-T thank MINECO for RyC contracts. A. P. thanks MINECO for JyC contrac