Locomotor Activity of Leaf Extracts of \u3cem\u3ePithecellobium dulce\u3c/em\u3e Benth.

Objective: To study Locomotor activity of aqueous and alcoholic extracts of leaves of Pithecellobium dulce Benth. Materials and methods: CNS depressant activity of leaf extracts of P. dulce was evaluated using actophotometer in albino mice. The potency of alcoholic and aqueous extracts of leaf was compared with that of chlorpromazine at a dose of 100 mg/kg. The acute toxicity was determined using albino mice. Results: Both extracts caused significant CNS depression action in albino mice. The activity of alcoholic extract was more, when compared to chlorpromazine. Conclusion: CNS depression action of extracts may be due to increase in the concentration of GABA in brain