Pyrrolcarboxamide derivatives for the inhbition of ERK5

4-Amine-substituted derivatives of pyrazolo[3,4-d]pyrimidine and their preparation, pharmaceutical compositions, and use as antitumor agents

Bondavalli F
Botta M
Manetti F
Donnini S
Schenone S
Ziche M.

January 2004

Title compds. I [R1 = cyclopropylamino, NHPr, pyrrolidin-1-yl, NHBu, NEt2, morpholin-4-yl, NHCH2CH2O...

1-(2-ALKOXY-5-CARBOXYPHENYL)-α, β-UNSATURATED KETONES, THEIR PREPARATION AND APPLICATION IN THERAPEUTICS

Tsotinis, Andreas
Calogeropoulou, Theodora
Roussakis, Christos
Roussis, Vassilios

March 2008

The present invnetion relates to the 1-(2-alkoxy-5-carboxyphenyl)-α, β - unsaturated ketone compound...

Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities

Gouda Ahmed M.
Abdelazeem Ahmed H.
Abdalla Ashraf N.
Ahmed Muhammad

September 2018

Towards optimization of the pyrrolizine-5-carboxamide scaffold, a novel series of six derivatives (4...

Pyrrolcarboxamide derivatives for the inhbition of erk5

Myers, Stephanie

The invention provides compounds of formula (I) or a tautomer, stereoisomer, N-oxide, pharmaceutical...

USE OF 2-OXO-2H-PYRROL-1(5H)-CARBOXAMIDE DERIVATIVES AS ANTI-HIV AGENTS AND PROCESS FOR THE PRODUCTION THEREOF

COSTA, Mirco
DELLA CA', Nicola

January 2017

The present pharmaceutical invention is related to the use, in the medical field, of 2-oxo-2h-pirrol...

4-(7H-Pyrrolo[2,3-D]pyrimidin-4-yl)-3,6-dihydropyridine-(2H)-carboxamide derivatives as Limk and/or Rock kinases inhibitors for use in the treatment of cancer

Routier, Sylvain
Bénédetti, Hélène
Vallée, Béatrice
Bonnet, Pascal
Plé, Karen
Aci-Seche, Samia
Ruchaud, Sandrine
Braka, Abdennour
Champire, Anthony
Andres, Christian R.
Vourc'H, Patrick

December 2021

The present invention concerns a compound of formula (I), in particular as LIMK and/or ROCK kinases ...

Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4

Tucker, Julie Ann
Myers, Stephanie M.
Miller, Duncan C.
Molyneux, Lauren
Arasta, Mercedes
Bawn, Ruth H.
Blackburn, Timothy J.
Cook, Simon J.
Edwards, Noel
Endicott, Jane A.
Golding, Bernard T.
Griffin, Roger J.
Hammonds, Tim
Hardcastle, Ian R.
Harnor, Suzannah J.
Heptinstall, Amy B.
Lochhead, Pamela A.
Martin, Mathew P.
Martin, Nick C.
Newell, David R.
Owen, Paul J.
Pang, Leon C.
Reuillon, Tristan
Rigoreau, Laurent J.M.
Thomas, Huw D.
Wang, Lan-Zhen
Wong, Ai-Ching
Noble, Martin E.M.
Wedge, Stephen R.
Cano, Celine

September 2019

Extracellular regulated kinase 5 (ERK5) signalling has been implicated in driving a number of cellul...

5-(PYRIMIDIN-4-YL)-2-(PYRROLIDIN-1-YL)NICOTINONITRILE COMPOUNDS AS IKKE, TBK1 AND/OR SIK2 KINASES INHIBITORS

Newton, G

August 2018

The invention provides compounds of formula (I) wherein R is −CH3 or −CH2CH3 and pharmaceutically ac...

Kinase inhibitors

Fischer, Peter
Fromont, Christophe
Stevenson, Brett
Butterworth, Sam
Iacobini, Greg
Greco, Graziella
Sanz, Miguel Garzon
Jones, Heulyn
Kaur, Divneet

November 2019

The present invention relates to certain 4-(substituted aniline)-2-(substituted piperidin-1-yl)pyrim...

COMPOUNDS AND USES THEREOF

BOTTA, MAURIZIO
DREASSI, ELENA
TINTORI, CRISTINA
VIGNAROLI, GIULIA
Angelucci, Adriano
Schenone, Silvia

January 2016

The present invention refers to 4-amino-substituted pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyr...

Pyrimidinone derivatives and uses thereof to neutralize the biological activity of chemokines

Bonnet, D. (Dominique)
Frossard, N. (Nelly)
Galzi, J. (Jean-Luc)
Guignabert, C. (Christophe)
Hibert, M. (Marcel)
Simonin, F. (Frédéric)
Muller, S. (Sylviane)

January 2018

A subject of the present invention is a compound having the general formula (I) a pharmaceutically a...

Cdc7 kinase inhibitors:5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding

Menichincheri, Maria
Albanese, Clara
Alli, Cristina
Ballinari, Dario
Bargiotti, Alberto
Caldarelli, Marina
Ciavolella, Antonella
Cirla, Alessandra
Colombo, Maristella
Colotta, Francesco
Croci, Valter
Dalessio, Roberto
Danello, Matteo
Ermoli, Antonella
Fiorentini, Francesco
Forte, Barbara
Galvani, Arturo
Giordano, Patrizia
Isacchi, Antonella
Martina, Katia
Molinari, Antonio
Moll, Jürgen K.
Montagnoli, Alessia
Orsini, Paolo
Orzi, Fabrizio
Pesenti, Enrico
Pillan, Antonio
Roletto, Fulvia
Scolaro, Alessandra
Tatò, Marco
Tibolla, Marcellino
Valsasina, Barbara
Varasi, Mario
Vianello, Paola
Volpi, Daniele
Santocanale, Corrado
Vanotti, Ermes

October 2010

Cdc7 serine/threonine kinase is a key regulator of DNA synthesis in eukaryotic organisms. Cdc7 inhib...

Annellated pyrrole compounds for cancer management

S. Laufer
V. Tomasi
E. Palazzini
M. Barbanti
GUARNIERI, TIZIANA
TAVOLARI, SIMONA

January 2008

The present invention relates to the use of annellated pyrrole compounds and in particular ML3000 (l...

4-Amine-substituted derivatives of pyrazolo[3,4-d]pyrimidine and their preparation, pharmaceutical compositions, and use as antitumor agents

Bondavalli F
Botta M
Manetti F
Donnini S
Schenone S
Ziche M.

January 2004

Title compds. I [R1 = cyclopropylamino, NHPr, pyrrolidin-1-yl, NHBu, NEt2, morpholin-4-yl, NHCH2CH2O...

1-(2-ALKOXY-5-CARBOXYPHENYL)-α, β-UNSATURATED KETONES, THEIR PREPARATION AND APPLICATION IN THERAPEUTICS

Tsotinis, Andreas
Calogeropoulou, Theodora
Roussakis, Christos
Roussis, Vassilios

March 2008

The present invnetion relates to the 1-(2-alkoxy-5-carboxyphenyl)-α, β - unsaturated ketone compound...

Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities

Gouda Ahmed M.
Abdelazeem Ahmed H.
Abdalla Ashraf N.
Ahmed Muhammad

September 2018

Towards optimization of the pyrrolizine-5-carboxamide scaffold, a novel series of six derivatives (4...

Pyrrolcarboxamide derivatives for the inhbition of erk5

Myers, Stephanie

The invention provides compounds of formula (I) or a tautomer, stereoisomer, N-oxide, pharmaceutical...

USE OF 2-OXO-2H-PYRROL-1(5H)-CARBOXAMIDE DERIVATIVES AS ANTI-HIV AGENTS AND PROCESS FOR THE PRODUCTION THEREOF

COSTA, Mirco
DELLA CA', Nicola

January 2017

The present pharmaceutical invention is related to the use, in the medical field, of 2-oxo-2h-pirrol...

4-(7H-Pyrrolo[2,3-D]pyrimidin-4-yl)-3,6-dihydropyridine-(2H)-carboxamide derivatives as Limk and/or Rock kinases inhibitors for use in the treatment of cancer

Routier, Sylvain
Bénédetti, Hélène
Vallée, Béatrice
Bonnet, Pascal
Plé, Karen
Aci-Seche, Samia
Ruchaud, Sandrine
Braka, Abdennour
Champire, Anthony
Andres, Christian R.
Vourc'H, Patrick

December 2021

The present invention concerns a compound of formula (I), in particular as LIMK and/or ROCK kinases ...

Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4

Tucker, Julie Ann
Myers, Stephanie M.
Miller, Duncan C.
Molyneux, Lauren
Arasta, Mercedes
Bawn, Ruth H.
Blackburn, Timothy J.
Cook, Simon J.
Edwards, Noel
Endicott, Jane A.
Golding, Bernard T.
Griffin, Roger J.
Hammonds, Tim
Hardcastle, Ian R.
Harnor, Suzannah J.
Heptinstall, Amy B.
Lochhead, Pamela A.
Martin, Mathew P.
Martin, Nick C.
Newell, David R.
Owen, Paul J.
Pang, Leon C.
Reuillon, Tristan
Rigoreau, Laurent J.M.
Thomas, Huw D.
Wang, Lan-Zhen
Wong, Ai-Ching
Noble, Martin E.M.
Wedge, Stephen R.
Cano, Celine

September 2019

Extracellular regulated kinase 5 (ERK5) signalling has been implicated in driving a number of cellul...

5-(PYRIMIDIN-4-YL)-2-(PYRROLIDIN-1-YL)NICOTINONITRILE COMPOUNDS AS IKKE, TBK1 AND/OR SIK2 KINASES INHIBITORS

Newton, G

August 2018

The invention provides compounds of formula (I) wherein R is −CH3 or −CH2CH3 and pharmaceutically ac...

Kinase inhibitors

Fischer, Peter
Fromont, Christophe
Stevenson, Brett
Butterworth, Sam
Iacobini, Greg
Greco, Graziella
Sanz, Miguel Garzon
Jones, Heulyn
Kaur, Divneet

November 2019

The present invention relates to certain 4-(substituted aniline)-2-(substituted piperidin-1-yl)pyrim...

COMPOUNDS AND USES THEREOF

BOTTA, MAURIZIO
DREASSI, ELENA
TINTORI, CRISTINA
VIGNAROLI, GIULIA
Angelucci, Adriano
Schenone, Silvia

January 2016

The present invention refers to 4-amino-substituted pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyr...

Pyrimidinone derivatives and uses thereof to neutralize the biological activity of chemokines

Bonnet, D. (Dominique)
Frossard, N. (Nelly)
Galzi, J. (Jean-Luc)
Guignabert, C. (Christophe)
Hibert, M. (Marcel)
Simonin, F. (Frédéric)
Muller, S. (Sylviane)

January 2018

A subject of the present invention is a compound having the general formula (I) a pharmaceutically a...

Cdc7 kinase inhibitors:5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding

Menichincheri, Maria
Albanese, Clara
Alli, Cristina
Ballinari, Dario
Bargiotti, Alberto
Caldarelli, Marina
Ciavolella, Antonella
Cirla, Alessandra
Colombo, Maristella
Colotta, Francesco
Croci, Valter
Dalessio, Roberto
Danello, Matteo
Ermoli, Antonella
Fiorentini, Francesco
Forte, Barbara
Galvani, Arturo
Giordano, Patrizia
Isacchi, Antonella
Martina, Katia
Molinari, Antonio
Moll, Jürgen K.
Montagnoli, Alessia
Orsini, Paolo
Orzi, Fabrizio
Pesenti, Enrico
Pillan, Antonio
Roletto, Fulvia
Scolaro, Alessandra
Tatò, Marco
Tibolla, Marcellino
Valsasina, Barbara
Varasi, Mario
Vianello, Paola
Volpi, Daniele
Santocanale, Corrado
Vanotti, Ermes

October 2010

Cdc7 serine/threonine kinase is a key regulator of DNA synthesis in eukaryotic organisms. Cdc7 inhib...

Annellated pyrrole compounds for cancer management

S. Laufer
V. Tomasi
E. Palazzini
M. Barbanti
GUARNIERI, TIZIANA
TAVOLARI, SIMONA

January 2008

The present invention relates to the use of annellated pyrrole compounds and in particular ML3000 (l...

4-Amine-substituted derivatives of pyrazolo[3,4-d]pyrimidine and their preparation, pharmaceutical compositions, and use as antitumor agents

Bondavalli F
Botta M
Manetti F
Donnini S
Schenone S
Ziche M.

January 2004

Title compds. I [R1 = cyclopropylamino, NHPr, pyrrolidin-1-yl, NHBu, NEt2, morpholin-4-yl, NHCH2CH2O...

1-(2-ALKOXY-5-CARBOXYPHENYL)-α, β-UNSATURATED KETONES, THEIR PREPARATION AND APPLICATION IN THERAPEUTICS

Tsotinis, Andreas
Calogeropoulou, Theodora
Roussakis, Christos
Roussis, Vassilios

March 2008

The present invnetion relates to the 1-(2-alkoxy-5-carboxyphenyl)-α, β - unsaturated ketone compound...

Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities

Gouda Ahmed M.
Abdelazeem Ahmed H.
Abdalla Ashraf N.
Ahmed Muhammad

September 2018

Towards optimization of the pyrrolizine-5-carboxamide scaffold, a novel series of six derivatives (4...

Pyrrolcarboxamide derivatives for the inhbition of ERK5

Abstract

Extracted data

Pyrrolcarboxamide derivatives for the inhbition of ERK5

Abstract

Extracted data

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