Hepatitis C virus (HCV) causes chronic infections in at least 150 million individuals worldwide. HCV has a narrow host range and robustly infects only humans and chimpanzees. The underlying mechanisms for this narrow host range are incompletely understood. At the level of entry, differences in the amino acid sequences between the human and mouse orthologues of two essential host factors, the tetraspanin CD81 and the tight junction protein occludin (OCLN), explain, at least in part, HCV's limited ability to enter mouse hepatocytes. We have previously shown that adenoviral or transgenic overexpression of human CD81 and OCLN facilitates HCV uptake into mouse hepatocytes in vitro and in vivo. In efforts to refine these models, we constructed kn...
Hepatitis C viruses (HCV) affect 170 million patients, but only a minority of patients develop sympt...
Hepatitis C virus (HCV) entry is dependent on CD81. To investigate whether the CD81 sequence is a de...
The lack of a suitable small animal model for the analysis of hepatitis C virus (HCV) infection has ...
Item does not contain fulltextHepatitis C virus (HCV) remains a major medical problem. Antiviral tre...
Hepatitis C virus (HCV) species tropism is incompletely understood. We have previously shown that at...
Hepatitis C virus (HCV) naturally infects only humans and chimpanzees. The determinants responsible ...
AbstractWe previously demonstrated that hepatitis C virus (HCV) binds to human CD81 through the E2 g...
Hepatitis C virus (HCV) naturally infects only humans and chimpanzees. The determinants responsible ...
AbstractHepatitis C virus (HCV) remains a major medical problem. In-depth study of HCV pathogenesis ...
An estimated number of 71 million people are living with chronic hepatitis C virus (HCV) infection w...
An estimated number of 71 million people are living with chronic hepatitis C virus (HCV) infection w...
Hepatitis C virus (HCV) has no animal reservoir, infecting only humans. To investigate species barri...
Hepatitis C virus (HCV) has no animal reservoir, infecting only humans. To investigate species barri...
Hepatitis C virus (HCV) is a major cause of liver disease worldwide. A better understanding of its l...
International audienceBackground and Aims: Numerous HCV entry factors have been identified, and yet ...
Hepatitis C viruses (HCV) affect 170 million patients, but only a minority of patients develop sympt...
Hepatitis C virus (HCV) entry is dependent on CD81. To investigate whether the CD81 sequence is a de...
The lack of a suitable small animal model for the analysis of hepatitis C virus (HCV) infection has ...
Item does not contain fulltextHepatitis C virus (HCV) remains a major medical problem. Antiviral tre...
Hepatitis C virus (HCV) species tropism is incompletely understood. We have previously shown that at...
Hepatitis C virus (HCV) naturally infects only humans and chimpanzees. The determinants responsible ...
AbstractWe previously demonstrated that hepatitis C virus (HCV) binds to human CD81 through the E2 g...
Hepatitis C virus (HCV) naturally infects only humans and chimpanzees. The determinants responsible ...
AbstractHepatitis C virus (HCV) remains a major medical problem. In-depth study of HCV pathogenesis ...
An estimated number of 71 million people are living with chronic hepatitis C virus (HCV) infection w...
An estimated number of 71 million people are living with chronic hepatitis C virus (HCV) infection w...
Hepatitis C virus (HCV) has no animal reservoir, infecting only humans. To investigate species barri...
Hepatitis C virus (HCV) has no animal reservoir, infecting only humans. To investigate species barri...
Hepatitis C virus (HCV) is a major cause of liver disease worldwide. A better understanding of its l...
International audienceBackground and Aims: Numerous HCV entry factors have been identified, and yet ...
Hepatitis C viruses (HCV) affect 170 million patients, but only a minority of patients develop sympt...
Hepatitis C virus (HCV) entry is dependent on CD81. To investigate whether the CD81 sequence is a de...
The lack of a suitable small animal model for the analysis of hepatitis C virus (HCV) infection has ...