Germline or somatic mutation(s) in BRCA1 is associated with a 40-50% lifetime risk of developing high grade serous ovarian cancer (HGSOC), which is one of the most aggressive subtypes of epithelial ovarian cancers. To design better therapeutic options for women with ovarian cancer, it is vital to understand the cell-of-origin and identify molecular factors that drive cells to tumorigenesis. Based on mouse models, transcriptomic profiles, and organoid studies, both ovarian surface epithelium (OSE) and fallopian tube epithelium (FTE) can be the cell-of-origin of HGSOC. However, identification of precancerous lesions in FTEs indicate that FTEs are more prone to tumorigenesis suggesting that they have higher potential of being the cell-of-origi...
Recent evidence indicates high-grade serous ovarian cancer originates from the fallopian tube epithe...
Ovarian cancer is the sixth most lethal cancer in women. Out of all ovarian cancers – the high grade...
SummaryHigh-grade serous ovarian carcinoma presents significant clinical and therapeutic challenges....
High grade serous ovarian cancer (HGSC), the most lethal and frequent type of epithelial ovarian can...
Studies of prophylactic salpingectomy specimens from BRCA1/2 mutation carriers, at risk for tubal an...
216 pagesHigh grade serous ovarian carcinoma (HGSOC) is the most lethal form of ovarian cancer and i...
Fallopian tube secretory epithelial cells (FTSECs) are likely the main precursor cell type of high-g...
High-grade serous epithelial ovarian cancer (HGSOC) is the fifth leading cause of cancer death in wo...
AbstractAlthough controversial, recent studies suggest that serous ovarian carcinomas may arise from...
Germline BRCA1 or BRCA2 mutations (mtBRCA1 and mtBRCA2) increase risk for high-grade serous ovarian ...
AbstractMicroinvasive carcinomas and high-grade intraepithelial neoplasms are commonly discovered wi...
Ovarian cancer is the most lethal cause of death from gynecological malignancies in the Western worl...
High-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), is the most comm...
Although controversial, recent studies suggest that serous ovarian carcinomas may arise from fallopi...
Epithelial ovarian cancer (EOC) is a heterogeneous disease with five histotypes: serous (high-grade ...
Recent evidence indicates high-grade serous ovarian cancer originates from the fallopian tube epithe...
Ovarian cancer is the sixth most lethal cancer in women. Out of all ovarian cancers – the high grade...
SummaryHigh-grade serous ovarian carcinoma presents significant clinical and therapeutic challenges....
High grade serous ovarian cancer (HGSC), the most lethal and frequent type of epithelial ovarian can...
Studies of prophylactic salpingectomy specimens from BRCA1/2 mutation carriers, at risk for tubal an...
216 pagesHigh grade serous ovarian carcinoma (HGSOC) is the most lethal form of ovarian cancer and i...
Fallopian tube secretory epithelial cells (FTSECs) are likely the main precursor cell type of high-g...
High-grade serous epithelial ovarian cancer (HGSOC) is the fifth leading cause of cancer death in wo...
AbstractAlthough controversial, recent studies suggest that serous ovarian carcinomas may arise from...
Germline BRCA1 or BRCA2 mutations (mtBRCA1 and mtBRCA2) increase risk for high-grade serous ovarian ...
AbstractMicroinvasive carcinomas and high-grade intraepithelial neoplasms are commonly discovered wi...
Ovarian cancer is the most lethal cause of death from gynecological malignancies in the Western worl...
High-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), is the most comm...
Although controversial, recent studies suggest that serous ovarian carcinomas may arise from fallopi...
Epithelial ovarian cancer (EOC) is a heterogeneous disease with five histotypes: serous (high-grade ...
Recent evidence indicates high-grade serous ovarian cancer originates from the fallopian tube epithe...
Ovarian cancer is the sixth most lethal cancer in women. Out of all ovarian cancers – the high grade...
SummaryHigh-grade serous ovarian carcinoma presents significant clinical and therapeutic challenges....