AbstractIntroductionChondral defects of the talus are common and their treatment is challenging.Source of dataRecent published literatures.Areas of agreementMembrane-induced Autologous Chondrocyte Implantation (mACI) and Autologous Matrix-Induced Chondrogenesis (AMIC) have been proposed as management for chondral defects of the talus.Areas of controversyIt is debated whether AMIC provides greater outcomes compared to mACI for chondral regeneration. Several clinical studies showed controversial results, and the best treatment has not yet been clarified.Growing pointsTo investigate whether AMIC provide superior outcomes than mACI at midterm follow-up.Areas timely for developing researchAMIC exhibits similar clinical results to mACI. However, ...