Transient receptor potential (TRP) ion channels are involved in a variety of fundamental physiological processes, and their malfunction produces numerous human diseases. Therefore, these proteins represent a class of attractive drug targets and a class of important off-targets for in vitro pharmacological profiling. In the past decades, the rapid progress in emerging functional assays and instrumentation has enabled to readily monitor thermoTRP channel activity, and to develop high throughput screening (HTS) assays for TPR drug discovery. Chronologically, functional methods for ion channels include the ligand binding assay, flux-based assay, electrophysiology, fluorescence-based assays, and, more recently, automated electrophysiologic...
Calcium (Ca2+) is perhaps the most versatile signaling molecule in cells. Ca2+ regulates a large num...
The transient receptor potential ankyrin (TRPA) channels are Ca2 -permeable nonselective cation chan...
The transient receptor potential (TRP) superfamily of ion channels in humans comprises voltage-gated...
The family of transient receptor potential (TRPs) channels contains 28 mammalian members, each a uni...
The canonical transient receptor potential channel subfamily (TRPC3, TRPC6, and TRPC7) contains Ca2+...
Calcium ions are critical for cellular signalling and impact almost all aspects of cellular life. T...
Ca2+ signaling influences nearly every aspect of cellular life. Transient receptor potential (TRP) i...
Human embryonic kidney cells 293 (HEK293) are widely used as cellular heterologous expression system...
Transient receptor potential canonical (TRPC) proteins assemble to form homo- or heterotetrameric, n...
The 28 mammalian members of the super-family of transient receptor potential (TRP) channels are cati...
The concentration of free cytosolic Ca(2+) and the voltage across the plasma membrane are major dete...
Transient receptor potential (TRP) cation channels play diverse roles in cellular Ca2+ signaling. Fi...
Proteins of the TRPC family can form many homo- and heterotetrameric cation channels permeable to Na...
Transient receptor potential-6 channels are widely expressed cation channels that play a role in reg...
Ion channel permeability and calcium ion (Ca2+) signalling are essential in regulating cellular resp...
Calcium (Ca2+) is perhaps the most versatile signaling molecule in cells. Ca2+ regulates a large num...
The transient receptor potential ankyrin (TRPA) channels are Ca2 -permeable nonselective cation chan...
The transient receptor potential (TRP) superfamily of ion channels in humans comprises voltage-gated...
The family of transient receptor potential (TRPs) channels contains 28 mammalian members, each a uni...
The canonical transient receptor potential channel subfamily (TRPC3, TRPC6, and TRPC7) contains Ca2+...
Calcium ions are critical for cellular signalling and impact almost all aspects of cellular life. T...
Ca2+ signaling influences nearly every aspect of cellular life. Transient receptor potential (TRP) i...
Human embryonic kidney cells 293 (HEK293) are widely used as cellular heterologous expression system...
Transient receptor potential canonical (TRPC) proteins assemble to form homo- or heterotetrameric, n...
The 28 mammalian members of the super-family of transient receptor potential (TRP) channels are cati...
The concentration of free cytosolic Ca(2+) and the voltage across the plasma membrane are major dete...
Transient receptor potential (TRP) cation channels play diverse roles in cellular Ca2+ signaling. Fi...
Proteins of the TRPC family can form many homo- and heterotetrameric cation channels permeable to Na...
Transient receptor potential-6 channels are widely expressed cation channels that play a role in reg...
Ion channel permeability and calcium ion (Ca2+) signalling are essential in regulating cellular resp...
Calcium (Ca2+) is perhaps the most versatile signaling molecule in cells. Ca2+ regulates a large num...
The transient receptor potential ankyrin (TRPA) channels are Ca2 -permeable nonselective cation chan...
The transient receptor potential (TRP) superfamily of ion channels in humans comprises voltage-gated...