GO analysis of DEGs (FC < -1.2, p < 0.05).

Bar graphs of enriched terms across the input gene list were obtained from the Metascape gene list analysis report for (A) the RS cortex of female APP/PS1 AD vs. WT mice, (B) the hippocampus of female APP/PS1 AD vs. WT mice, (C) the RS cortex of male APP/PS1 AD vs. WT mice and (D) the hippocampus of male APP/PS1 AD vs. WT mice. The individual categories are provided together with their related -Log(10)P values in a descending fashion. Note that no GO analysis results could be obtained in the RS cortex of female APP/PS1 AD mice vs. WT controls. Overall, GO analysis for downregulated gene candidates revealed a limited number of categories compared to upregulated gene candidates (see also Fig 2).