SARS-CoV-2 perinatal transmission and neonatal outcomes across four different waves of COVID-19 pandemic: A nationwide prospective cohort study from the Italian Society of Neonatology
- Lorenza Pugni
- Beatrice Letizia Crippa
- Francesco Raimondi
- Giovanni Vento
- Giovanna Mangili
- Alessandra Coscia
- Giacomo Artieri
- Andrea Ronchi
- Maria Luisa Ventura
- Paola Lago
- Carlo Pietrasanta
- Riccardo Crimi
- Giuseppina Bonfante
- Serafina Perrone
- Alessandra Boncompagni
- Agostina Solinas
- Massimo Agosti
- Chiara Poggi
- Alessandra Falcone
- Claudia Pagliotta
- Daniela Gianotti
- Genny Gottardi
- Giulia Paviotti
- Alessandra Allodi
- Gianfranco Maffei
- Alice Proto
- Antonella Travierso
- Serena Salomè
- Simonetta Costa
- Stefania Ferrari
- Chiara Peila
- Mariateresa Sinelli
- Federica Fanelli
- Lucia Giordano
- Martina Saruggia
- Letizia Capasso
- Elena Spada
- Camilla Gizzi
- Luigi Orfeo
- Fabio Mosca
DOIAbstract
Objectives: To describe how SARS-CoV-2 infection at the time of delivery affected maternal and neonatal outcomes across four major waves of the COVID-19 pandemic in Italy. Methods: This is a large, prospective, nationwide cohort study collecting maternal and neonatal data in case of maternal peripartum SARS-CoV-2 infection between February 2020 and March 2022. Data were stratified across the four observed pandemic waves. Results: Among 5201 COVID-19-positive mothers, the risk of being symptomatic at delivery was significantly higher in the first and third waves (20.8-20.8%) than in the second and fourth (13.2-12.2%). Among their 5284 neonates, the risk of prematurity (gestational age <37 weeks) was significantly higher in the first and thir...
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