Malware (Malicious Software) is any software which performs malicious activities on computer-based systems without the user's consent. The number, severity, and complexity of malware have been increasing recently. The detection of malware becomes challenging because new malware variants are using obfuscation techniques to hide themselves from the malware detection systems. In this paper, a new behavioral-based malware detection method is proposed based on file-registry operations. When malware features are generated, only the operations which are performed on specific file and registry locations are considered. The file-registry operations divided into five groups: autostart file locations, temporary file locations, specific system file lo...