The predicted (blue markers) and actual proportions (orange markers) of individuals that experience adverse events related to a particular organ or body tissue (represented on the x-axis). The line connecting the marker represents the observed error between the predicted proportion of individuals that would experience adverse events against the actual proportion reported in clinical trials. Each prediction is obtained using a trained model without using the corresponding (held out) observations reported in breast cancer clinical trials that treated patients with gemcitabine. (EPS)</p
Adverse events (AEs) and concomitant medications (CMs) underreporting remains a recurrent issue in c...
<p>Abbreviation: NSCLC, non-small-cell lung cancer; MBC, metastatic breast cancer;</p>1<p>gemcitabin...
Cancer chemotherapeutic agents have a low therapeutic index and require a precise and safe prescript...
(A) A scatter plot showing the predicted response (y-axis) of the machine learning model plotted aga...
<p>GEM, gemcitabine; TRs, toxicity rates; OR, odds ratio; CI, confidence interval.</p
<p>Comparison of objective response rate and toxicity in therapy subgroups by type of malignancy.</p
<p>(A) The tumor volume curve during treatment. Arrows indicate the time of injection. The day when ...
Observational drug safety studies may be susceptible to confounding or protopathic bias. This bias m...
Observational drug safety studies may be susceptible to confounding or protopathic bias. This bias m...
Observational drug safety studies may be susceptible to confounding or protopathic bias. This bias m...
The visual predictive checks were simulated for 1,000 patients and are shown for all 7 drugs and 9 l...
Patients with breast cancer receiving chemotherapy are at risk of developing toxicities which can be...
Mean enrichment of predicted (A) OGs and (B) TS and LOFs with experimental data. The error bars show...
(A) Distribution of adverse events reported in the clinical trial of breast cancer for drugs that ta...
<p>Footnotes: Hazard ratios when comparing each regimen with Gemcitabine (G), projected median overa...
Adverse events (AEs) and concomitant medications (CMs) underreporting remains a recurrent issue in c...
<p>Abbreviation: NSCLC, non-small-cell lung cancer; MBC, metastatic breast cancer;</p>1<p>gemcitabin...
Cancer chemotherapeutic agents have a low therapeutic index and require a precise and safe prescript...
(A) A scatter plot showing the predicted response (y-axis) of the machine learning model plotted aga...
<p>GEM, gemcitabine; TRs, toxicity rates; OR, odds ratio; CI, confidence interval.</p
<p>Comparison of objective response rate and toxicity in therapy subgroups by type of malignancy.</p
<p>(A) The tumor volume curve during treatment. Arrows indicate the time of injection. The day when ...
Observational drug safety studies may be susceptible to confounding or protopathic bias. This bias m...
Observational drug safety studies may be susceptible to confounding or protopathic bias. This bias m...
Observational drug safety studies may be susceptible to confounding or protopathic bias. This bias m...
The visual predictive checks were simulated for 1,000 patients and are shown for all 7 drugs and 9 l...
Patients with breast cancer receiving chemotherapy are at risk of developing toxicities which can be...
Mean enrichment of predicted (A) OGs and (B) TS and LOFs with experimental data. The error bars show...
(A) Distribution of adverse events reported in the clinical trial of breast cancer for drugs that ta...
<p>Footnotes: Hazard ratios when comparing each regimen with Gemcitabine (G), projected median overa...
Adverse events (AEs) and concomitant medications (CMs) underreporting remains a recurrent issue in c...
<p>Abbreviation: NSCLC, non-small-cell lung cancer; MBC, metastatic breast cancer;</p>1<p>gemcitabin...
Cancer chemotherapeutic agents have a low therapeutic index and require a precise and safe prescript...