Comparison of the output ERK-PP and Raf* for the reference simulation (solid lines) and a modified model (dashed lines) with no degradation from six internalised receptor species (those with degradation reaction in Fig 9, realised by classifying the degradation products as cneg).</p
<p>Receptor tyrosine kinase phosphorylation was determined by a commercial kit (Proteome Profiler Hu...
<p>Using experimental data and first-order decay curves, degradation coefficients of (A) Vif, (B) A3...
In a previous report we described the use of flunitrazepam as a photoaffinity label to monitor the t...
<p>(<b>A</b>) Different rates of I-Smad-induced Receptor Degradation (<i>klid</i> = 10<sup>−6</sup>∼...
<p>Error bars denote standard errors for each point based on 3 repetitions. Upon pre-incubation in10...
<p>Concentration-time profiles of LRS and LRI computed at two values of the endocytic downregulation...
<p>Model profiles of Syk activity are the result of a series of simulations where the ligand is decr...
<p>(A) as a function of . Error bars are obtained from many numerical realizations (between ) and r...
<p>They are the same as those used by <a href="http://www.plosone.org/article/info:doi/10.1371/journ...
A: State classification indices for Phosphatase1; B: comparison of the output ERK-PP and Phosphatase...
The model incorporates the formation of receptor-ligand complex from extracellular IL-2 and receptor...
<p>(A) The root-mean-square deviation (RMSD) for C<sub>α</sub> atoms of the protein (B) Potential en...
<p>A) Ligand-receptor cooperativity for RTK submodel (dots-deterministic simulations; lines- hill eq...
Local sensitivity analysis was performed by examining the sensitivity of model outputs (total recept...
<p><i>*</i>Values correspond to steady-state conditions in single-expressing cells where the total n...
<p>Receptor tyrosine kinase phosphorylation was determined by a commercial kit (Proteome Profiler Hu...
<p>Using experimental data and first-order decay curves, degradation coefficients of (A) Vif, (B) A3...
In a previous report we described the use of flunitrazepam as a photoaffinity label to monitor the t...
<p>(<b>A</b>) Different rates of I-Smad-induced Receptor Degradation (<i>klid</i> = 10<sup>−6</sup>∼...
<p>Error bars denote standard errors for each point based on 3 repetitions. Upon pre-incubation in10...
<p>Concentration-time profiles of LRS and LRI computed at two values of the endocytic downregulation...
<p>Model profiles of Syk activity are the result of a series of simulations where the ligand is decr...
<p>(A) as a function of . Error bars are obtained from many numerical realizations (between ) and r...
<p>They are the same as those used by <a href="http://www.plosone.org/article/info:doi/10.1371/journ...
A: State classification indices for Phosphatase1; B: comparison of the output ERK-PP and Phosphatase...
The model incorporates the formation of receptor-ligand complex from extracellular IL-2 and receptor...
<p>(A) The root-mean-square deviation (RMSD) for C<sub>α</sub> atoms of the protein (B) Potential en...
<p>A) Ligand-receptor cooperativity for RTK submodel (dots-deterministic simulations; lines- hill eq...
Local sensitivity analysis was performed by examining the sensitivity of model outputs (total recept...
<p><i>*</i>Values correspond to steady-state conditions in single-expressing cells where the total n...
<p>Receptor tyrosine kinase phosphorylation was determined by a commercial kit (Proteome Profiler Hu...
<p>Using experimental data and first-order decay curves, degradation coefficients of (A) Vif, (B) A3...
In a previous report we described the use of flunitrazepam as a photoaffinity label to monitor the t...
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