Reducing cytoplasmic resistivity (R_a) has no effect on the fundamental outcomes of computational modeling of dSPN dendritic activity.

The simulations in this figure are identical to those of Fig 5, except cytoplasmic resistivity (Ra) is reduced from 200 to 100 Ω cm and the underlying conductances of synaptically activated glutamatergic AMPA and NMDARs are increased by 60% (from 350 and 752.5 to 560 and 1,204 pS, respectively). The latter ensures that a glutamatergic synaptic event at a given spine produces a similar depolarization at its equivalent dendritic location (i.e., as measured in the dendritic tree at the location of its spine neck). As a result, the number of clustered inputs that was just subthreshold for upstate generation (15) was preserved. Any qualitative differences (small increases in “quarterdrop duration” (B and C) and somatic amplitude (B, C, F, and I) can be attributed to the effect of reduced dendritic filtering resulting from reduced Ra. The data underlying the graphs shown in the figure can be found in dx.doi.org/10.5281/zenodo.10387118. (EPS)