System-Level Integration And Packaging Of Nanosensor Embedded Microfluidics With Electrical Readout

The development of innovative biosensor technologies necessitates the smooth integration of electronic and microfluidic components. Researchers often find themselves expending significant effort and financial resources in the pursuit of parameter optimization, all the while experiencing challenges with complex system designs. Unfortunately, literature in this domain often suffers from a lack of comprehensive methodological elucidation. In the present thesis, the focus is on designing the auxiliary features that make chip's sensing region useful. In particular, the design and fabrication of electrical readout connections to a sensitive region comprising parallel arrangement of 100 µm long nanoscale sensing elements and its interfacing to a microfluidic analyte are studied by utilization of the most commonly used materials of microfluidics studies, namely PDMS and SU-8. Each parameter is thoroughly investigated by considering the microfluidic channel dimensions, geometries, and connection schemes to enhance the overall design’s precision. The outcome catalogue can be utilized as a generic tool for developing lab-on-a-chip devices for point-of-care applications, particularly in the field of disease diagnostics