Background: Mobile elements are active in the human genome, both in the germline and cancers, where they can mutate driver genes.Results: While analysing whole genome paired-end sequencing of oesophageal adenocarcinomas to find genomic rearrangements, we identified three ways in which new mobile element insertions appear in the data, resembling translocation or insertion junctions: inserts where unique sequence has been transduced by an L1 (Long interspersed element 1) mobile element; novel inserts that are confidently, but often incorrectly, mapped by alignment software to L1s or polyA tracts in the reference sequence; and a combination of these two ways, where different sequences within one insert are mapped to different loci. We identifi...
Mobile elements constitute greater than 45% of the human genome as a result of repeated insertion ev...
About half of all cancers have somatic integrations of retrotransposons. Here, to characterize their...
Long interspersed nuclear element-1 (L1) retrotransposons are mobile repetitive elements that are ab...
BACKGROUND: Mobile elements are active in the human genome, both in the germline and cancers, where ...
Background: Mobile elements are active in the human genome, both in the germline and cancers, where ...
Oesophageal adenocarcinoma (OAC) provides an ideal case study to characterize large-scale rearrangem...
The non-coding regions of tumour cell genomes harbour a considerable fraction of total DNA sequence ...
Abstract: We show that introns harboring translocation breakpoints in tumors are significantly longe...
About half of all cancers have somatic integrations of retrotransposons. Here, to characterize their...
SummaryCharacterizing structural variants in the human genome is of great importance, but a genome w...
Somatic transposon mutagenesis in mice is an efficient strategy to investigate the genetic mechanism...
Abstract While mobile elements are largely inactive in healthy somatic tissues, increased activity h...
<p>(A) DNA sequence and insertion frequency of the 10 most commonly inserted sequences identified wi...
Somatic genome rearrangements are thought to play important roles in cancer development. We optimize...
Abstract Background Transposable elements make up a significant portion of the human genome. Accurat...
Mobile elements constitute greater than 45% of the human genome as a result of repeated insertion ev...
About half of all cancers have somatic integrations of retrotransposons. Here, to characterize their...
Long interspersed nuclear element-1 (L1) retrotransposons are mobile repetitive elements that are ab...
BACKGROUND: Mobile elements are active in the human genome, both in the germline and cancers, where ...
Background: Mobile elements are active in the human genome, both in the germline and cancers, where ...
Oesophageal adenocarcinoma (OAC) provides an ideal case study to characterize large-scale rearrangem...
The non-coding regions of tumour cell genomes harbour a considerable fraction of total DNA sequence ...
Abstract: We show that introns harboring translocation breakpoints in tumors are significantly longe...
About half of all cancers have somatic integrations of retrotransposons. Here, to characterize their...
SummaryCharacterizing structural variants in the human genome is of great importance, but a genome w...
Somatic transposon mutagenesis in mice is an efficient strategy to investigate the genetic mechanism...
Abstract While mobile elements are largely inactive in healthy somatic tissues, increased activity h...
<p>(A) DNA sequence and insertion frequency of the 10 most commonly inserted sequences identified wi...
Somatic genome rearrangements are thought to play important roles in cancer development. We optimize...
Abstract Background Transposable elements make up a significant portion of the human genome. Accurat...
Mobile elements constitute greater than 45% of the human genome as a result of repeated insertion ev...
About half of all cancers have somatic integrations of retrotransposons. Here, to characterize their...
Long interspersed nuclear element-1 (L1) retrotransposons are mobile repetitive elements that are ab...