There is a growing interest in the use of cyclic peptides as therapeutics, but their efficient production is often the bottleneck in taking them forward in the development pipeline. We have recently developed a method to synthesise azole-containing cyclic peptides using enzymes derived from different cyanobactin biosynthetic pathways. Accurate quantification is crucial for calculation of the reaction yield and for the downstream biological testing of the products. In this study, we demonstrate the development and validation of two methods to accurately quantify these compounds in the reaction mixture and after purification. The first method involves the use of a HPLC coupled in parallel to an ESMS and an ICPMS, hence correlating the calcula...
Currently, the detection/quantitation of biomolecules using Inductively Coupled Plasma Mass Spectrom...
Cyclic peptides comprise a large and important class of biologically active molecules. They are gene...
Naturally occurring azole-enriched cyclic peptides have broad biological and pharmacological activit...
There is a growing interest in the use of cyclic peptides as therapeutics, but their efficient produ...
Heterocycle‐containing cyclic peptides are promising scaffolds for the pharmaceutical industry but t...
Heterocycle-containing cyclic peptides are promising scaffolds for the pharmaceutical industry but t...
Cyclic disulfide-rich peptides ranging in size from ∼14 to 29 amino acids have been found in a wide ...
Cyclic tetrapeptides are a class of natural products that have been shown to have broad ranging biol...
International audienceTwo cyclic peptides have been prepared and characterized by MS and NMR. The li...
Heterocycle-containing cyclic peptides are promising scaffolds for the pharmaceutical industry but t...
The synthesis of large numbers of cyclic peptides-required, for example, in screens for drug develop...
Cyclic peptides are increasingly employed as chemical tools in biology and drug discovery. They have...
Macrocyclic, disulfide-rich peptides have found widespread applications in drug design and developme...
Bioactive peptides are catching great interests for the last few decades. They find several applicat...
This work was supported by the European Research Council (339367), UK Biotechnology and Biological S...
Currently, the detection/quantitation of biomolecules using Inductively Coupled Plasma Mass Spectrom...
Cyclic peptides comprise a large and important class of biologically active molecules. They are gene...
Naturally occurring azole-enriched cyclic peptides have broad biological and pharmacological activit...
There is a growing interest in the use of cyclic peptides as therapeutics, but their efficient produ...
Heterocycle‐containing cyclic peptides are promising scaffolds for the pharmaceutical industry but t...
Heterocycle-containing cyclic peptides are promising scaffolds for the pharmaceutical industry but t...
Cyclic disulfide-rich peptides ranging in size from ∼14 to 29 amino acids have been found in a wide ...
Cyclic tetrapeptides are a class of natural products that have been shown to have broad ranging biol...
International audienceTwo cyclic peptides have been prepared and characterized by MS and NMR. The li...
Heterocycle-containing cyclic peptides are promising scaffolds for the pharmaceutical industry but t...
The synthesis of large numbers of cyclic peptides-required, for example, in screens for drug develop...
Cyclic peptides are increasingly employed as chemical tools in biology and drug discovery. They have...
Macrocyclic, disulfide-rich peptides have found widespread applications in drug design and developme...
Bioactive peptides are catching great interests for the last few decades. They find several applicat...
This work was supported by the European Research Council (339367), UK Biotechnology and Biological S...
Currently, the detection/quantitation of biomolecules using Inductively Coupled Plasma Mass Spectrom...
Cyclic peptides comprise a large and important class of biologically active molecules. They are gene...
Naturally occurring azole-enriched cyclic peptides have broad biological and pharmacological activit...