An enzymatic route to selenazolines
- Koehnke, Jesko
- Morawitz, Falk
- Bent, Andrew F.
- Houssen, Wael E.
- Shirran, Sally L.
- Fuszard, Matthew A.
- Smellie, Iain A.
- Botting, Catherine H.
- Smith, Margaret C. M.
- Jaspars, Marcel
- Naismith, James H.
Publication date
March 2013
DOIAbstract
Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates oxazolines and thiazolines from serines/threonines and cysteines.</p
Extracted data
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