Synthesis of biaryl, arylamine and aryl ketone compounds using a commercially available air- and moisture-stable palladium catalyst

A commercially available palladium complex bearing a N-heterocyclic carbene (NHC) was used in gram-scale synthesis of three compounds, a biaryl, an arylamine and an aryl ketone. The syntheses were performed in catalytic fashion using a Suzuki-Miyaura, a Buchwald-Hartwig and a ketone arylation reaction protocol. These three reactions were carried out using the same palladium pre-catalyst.