Evidence for the intrarenal renin-angiotensin system in the European lesser-spotted dogfish

The existence of an intrarenal renin-angiotensin system (RAS) in a perfused European lesser-spotted dogfish Scyliorhinus canicula trunk preparation was examined by the inhibition of angiotensin-converting enzyme by captopril. This resulted in a glomerular diuresis, an increase in urea and chloride clearance and excretion, and an increase in transport maxima for glucose. It is proposed that these results suggest the presence of an intrarenal RAS. (C) 2003 The Fisheries Society of the British Isles.