Add to ORKGThe reaction of a monocyclic gamma-lactam with the serine protease elastase occurs via reversible formation of a hydrolytically labile acyl-enzyme complex; in contrast analogous beta-lactam inhibitors irreversibly react to form a relatively stable acyl-enzyme complex. (C) 1997 Elsevier Science Ltd.</p
Some monocyclic beta-lactam derivatives of types II (1a-5a) and III (1b-5b), designed as analogs of ...
sis [4–8] and structural [9–11] work identified key cata-lytic residues. Subsequent X-ray crystallog...
A new class of inhibitors 4-oxo-beta-lactams (azetidine-2,4-diones), containing the required structu...
The reaction of a monocyclic gamma-lactam with the serine protease elastase occurs via reversible fo...
The reaction of a monocyclic γ-lactam with the serine protease elastase occurs via reversible format...
The reaction of a monocyclic gamma-lactam with the serine protease elastase occurs via reversible fo...
beta-Lactam inhibitors of transpeptidase enzymes involved in cell wall biosynthesis remain among the...
beta-Lactams inhibit a range of enzymes via acylation of nucleophilic serine residues. Certain gamma...
Although originally discovered as inhibitors of pencillin-binding proteins, beta-lactams have more r...
Although originally discovered as inhibitors of pencillin-binding proteins, beta-lactams have more r...
A series of bicyclic trans-fused -lactones and -lactams have been previously described for the inhib...
The presence of a leaving group at C- 4 of monobactams is usually considered to be a requirement for...
-Sultams are the sulfonyl analogues of -lactams, and 3-oxo- -sultams are both -lactams and -sultam...
Cefoxitin and other beta-lactam antibiotics with a methoxy group on the alpha-face behave as very po...
Whereas the beta-lactam acylases are traditionally used for the hydrolytic processing of penicillin ...
Some monocyclic beta-lactam derivatives of types II (1a-5a) and III (1b-5b), designed as analogs of ...
sis [4–8] and structural [9–11] work identified key cata-lytic residues. Subsequent X-ray crystallog...
A new class of inhibitors 4-oxo-beta-lactams (azetidine-2,4-diones), containing the required structu...
The reaction of a monocyclic gamma-lactam with the serine protease elastase occurs via reversible fo...
The reaction of a monocyclic γ-lactam with the serine protease elastase occurs via reversible format...
The reaction of a monocyclic gamma-lactam with the serine protease elastase occurs via reversible fo...
beta-Lactam inhibitors of transpeptidase enzymes involved in cell wall biosynthesis remain among the...
beta-Lactams inhibit a range of enzymes via acylation of nucleophilic serine residues. Certain gamma...
Although originally discovered as inhibitors of pencillin-binding proteins, beta-lactams have more r...
Although originally discovered as inhibitors of pencillin-binding proteins, beta-lactams have more r...
A series of bicyclic trans-fused -lactones and -lactams have been previously described for the inhib...
The presence of a leaving group at C- 4 of monobactams is usually considered to be a requirement for...
-Sultams are the sulfonyl analogues of -lactams, and 3-oxo- -sultams are both -lactams and -sultam...
Cefoxitin and other beta-lactam antibiotics with a methoxy group on the alpha-face behave as very po...
Whereas the beta-lactam acylases are traditionally used for the hydrolytic processing of penicillin ...
Some monocyclic beta-lactam derivatives of types II (1a-5a) and III (1b-5b), designed as analogs of ...
sis [4–8] and structural [9–11] work identified key cata-lytic residues. Subsequent X-ray crystallog...
A new class of inhibitors 4-oxo-beta-lactams (azetidine-2,4-diones), containing the required structu...