1. A two-microelectrode voltage clamp was used to determine the effects of n-butanol, n-hexanol, n-octanol, n-decanol and methyl hexanoate on a transient potassium (IA) current in identified Helix aspersa neurones. Experiments were carried out at a temperature of 10-12 degrees C. 2. Each n-alkanol reversibly reduced the amplitude of the IA current. Logarithmic dose-response curves for the current reduction by each homologue were sigmoidal and had slope factors of around four. The concentrations required to reduce the peak (with time) current at -30 mV by 50% (ED50 +/- fitted standard error) were: 57 +/- 5 mM (n-butanol); 2.0 +/- 0.1 mM (n-hexanol); 0.28 +/- 0.02 mM (n-octanol) and 0.016 +/- 0.001 mM (n-decanol). Methyl hexanoate also reduce...
AbstractThis is part of a continuing patch-clamp study exploring molecular actions of anesthetics an...
The chemical modifiers N-bromoacetamide (NBA), N-bromo-succinimide (NBS), and chloramine-T (ChT) are...
The effect of extracellular potassium concentration on the membrane electrical activity has been stu...
1. A two-microelectrode voltage clamp was used to determine the effects of n-butanol, n-hexanol, n-o...
Many effects of short-chain phospholipids and n-alkanes on the squid axon sodium current (INa) are c...
The effects of n-octanol and n-decanol on nerve membrane sodium channels were examined in internally...
It is not known whether alcohols modulate ion channels by directly binding to the channel protein or...
The responses of Helix aspersa neurones to acetylcholine ware observed using a Ramped Voltage Clamp ...
1. The effects of clinical inhalation anaesthetics, such as halothane and methoxyflurane, and "model...
The effects of the homologous series of carboxylic esters, methyl propionate to methyl decanoate, on...
Alkanols are small aliphatic compounds that inhibit voltage-gated K+ (K-v) channels through a yet un...
SIGLEAvailable from British Library Document Supply Centre- DSC:DX188527 / BLDSC - British Library D...
The effect of several chemical reagents on the sodium current was studied in voltage-clamped single ...
SIGLEAvailable from British Library Document Supply Centre- DSC:DX178378 / BLDSC - British Library D...
AbstractThe effect of arachidonic acid on the A current (IA) has been studied in dissociated bullfro...
AbstractThis is part of a continuing patch-clamp study exploring molecular actions of anesthetics an...
The chemical modifiers N-bromoacetamide (NBA), N-bromo-succinimide (NBS), and chloramine-T (ChT) are...
The effect of extracellular potassium concentration on the membrane electrical activity has been stu...
1. A two-microelectrode voltage clamp was used to determine the effects of n-butanol, n-hexanol, n-o...
Many effects of short-chain phospholipids and n-alkanes on the squid axon sodium current (INa) are c...
The effects of n-octanol and n-decanol on nerve membrane sodium channels were examined in internally...
It is not known whether alcohols modulate ion channels by directly binding to the channel protein or...
The responses of Helix aspersa neurones to acetylcholine ware observed using a Ramped Voltage Clamp ...
1. The effects of clinical inhalation anaesthetics, such as halothane and methoxyflurane, and "model...
The effects of the homologous series of carboxylic esters, methyl propionate to methyl decanoate, on...
Alkanols are small aliphatic compounds that inhibit voltage-gated K+ (K-v) channels through a yet un...
SIGLEAvailable from British Library Document Supply Centre- DSC:DX188527 / BLDSC - British Library D...
The effect of several chemical reagents on the sodium current was studied in voltage-clamped single ...
SIGLEAvailable from British Library Document Supply Centre- DSC:DX178378 / BLDSC - British Library D...
AbstractThe effect of arachidonic acid on the A current (IA) has been studied in dissociated bullfro...
AbstractThis is part of a continuing patch-clamp study exploring molecular actions of anesthetics an...
The chemical modifiers N-bromoacetamide (NBA), N-bromo-succinimide (NBS), and chloramine-T (ChT) are...
The effect of extracellular potassium concentration on the membrane electrical activity has been stu...