Distinct pathways of ribonucleoprotein transport exist within the nucleus, connected to their biogenesis and maturation. These occur despite evidence that the major mechanism for their movement within the nucleus is passive diffusion. Using fusions of Sm proteins to YFP, CFP and photoactivatable GFP, I have demonstrated that pathways with uni-directional bulk flow of complexes can be maintained within the nucleus despite multi-directional exchange of individual complexes. Newly imported splicing small nuclear ribonucleoproteins (snRNPs) exchange between Cajal bodies (CBs) within a nucleus and access the cytoplasm, but are unable to accumulate in speckles. By contrast, snRNPs at steady-state exchange freely in any direction between CBs and s...
SummaryCRM1 is the major nuclear export receptor. During translocation through the nuclear pore, tra...
The nucleus is a vital sub cellular compartment and it stores the genome. Transport across the nucl...
Transport of C/D snoRNPs to nucleoli involves nuclear export factors. In particular, CRM1 binds nasc...
Distinct pathways of ribonucleoprotein transport exist within the nucleus, connected to their biogen...
AbstractCRM1 is distantly related to receptors that mediate nuclear protein import and was previousl...
The Ran GTPase activating protein RanGAP1 plays an essential role in nuclear transport by stimulatin...
Nucleocytoplasmic traffic is one of the hallmarks of the eukaryotic cell. To a large extent, this pr...
doi:10.1111/febs.12842 Nucleocytoplasmic trafficking in eukaryotic cells is a highly regulated and c...
CRM1 is an export factor that, together with its adaptor NMd3, transports numerous cargo molecules f...
CRM1 is a highly conserved, RanGTPase-driven exportin that caries proteins and RNPs from the nucleus...
The transport receptor Crm1 mediates the export of diverse cargos containing leucine-rich nuclear ex...
Background: Small nuclear ribonucleoproteins (snRNPs), which are essential components of the mRNA sp...
In eukaryotes, the nucleocytoplasmic transport of macromolecules is mainly mediated by soluble nucle...
SummaryCRM1 is the major nuclear export receptor. During translocation through the nuclear pore, tra...
The nucleus is a vital sub cellular compartment and it stores the genome. Transport across the nucl...
Transport of C/D snoRNPs to nucleoli involves nuclear export factors. In particular, CRM1 binds nasc...
Distinct pathways of ribonucleoprotein transport exist within the nucleus, connected to their biogen...
AbstractCRM1 is distantly related to receptors that mediate nuclear protein import and was previousl...
The Ran GTPase activating protein RanGAP1 plays an essential role in nuclear transport by stimulatin...
Nucleocytoplasmic traffic is one of the hallmarks of the eukaryotic cell. To a large extent, this pr...
doi:10.1111/febs.12842 Nucleocytoplasmic trafficking in eukaryotic cells is a highly regulated and c...
CRM1 is an export factor that, together with its adaptor NMd3, transports numerous cargo molecules f...
CRM1 is a highly conserved, RanGTPase-driven exportin that caries proteins and RNPs from the nucleus...
The transport receptor Crm1 mediates the export of diverse cargos containing leucine-rich nuclear ex...
Background: Small nuclear ribonucleoproteins (snRNPs), which are essential components of the mRNA sp...
In eukaryotes, the nucleocytoplasmic transport of macromolecules is mainly mediated by soluble nucle...
SummaryCRM1 is the major nuclear export receptor. During translocation through the nuclear pore, tra...
The nucleus is a vital sub cellular compartment and it stores the genome. Transport across the nucl...
Transport of C/D snoRNPs to nucleoli involves nuclear export factors. In particular, CRM1 binds nasc...