Simulation results for the Bilinear growth rate modulation.

(A–D) Three-dimensional (3D) volumetric plots showing how the change in cell mass CV throughout the cell cycle responds to the means of γ′ and , represented by μα′ and , when applying variability (CV) to only 1 parameter of α′ (A), γ′ (B), (C), or equal variability to all 3 parameters (D). The slice planes are orthogonal to the CV axis at CV = 0.2. (E, F) Contour plots illustrating the change in cell mass CV during the G1 (E) and nonG1 phases (F) with the means of γ′ and when assuming a 30% CV in α′. (G, H) Contour plots illustrating the change in cell mass CV during the G1 (G) and nonG1 phases (H) with means of γ′ and when assuming a 40% CV in α′. Solid circles in (E–H) indicate the corresponding positions in the contour plots when adopting parameter values from the experimental data. The data underlying this figure and the scripts used to generate the plots are available on the Open Science Framework at osf.io/3kyvw. (EPS)