Delayed Afterdepolarization (DAD) activity window of the rabbit Purkinje cell model.
- Anthony Owusu-Mensah (17743167)
- Jacqueline Treat (17743170)
- Joyce Bernardi (6187244)
- Ryan Pfeiffer (624958)
- Robert Goodrow (17743173)
- Bright Tsevi (10977537)
- Victoria Lam (17743176)
- Michel Audette (13801143)
- Jonathan M. Cordeiro (9660155)
- Makarand Deo (10977549)
Publication date
January 2024
DOIAbstract
A. Intracellular calcium concentration within the junctional SR of rabbit Purkinje cell (RPC) model during action potential (AP) for various percentages of IKr block (0%, 50%, and 100%). 100% IKr blockade produced DAD. B. Intracellular calcium in the cytosol of the rabbit Purkinje cell (RPC) model for various percentages of IKr block (0%, 50%, and 100%). C. Simulated AP of rabbit Purkinje cell (RPC) model for 100% IKr block. D. Current tracing of the various ionic currents that underlie the RPC model AP for 100% IKr blockade within a DAD activity window. Within a DAD activity window, the sodium-potassium exchanger current (INCX) and the inward rectifying potassium current (IK1) do not get to zero at the resting phase of AP.</p
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