Bar plot, at 72h, of the best dose-effect combination of MK-1775 with BAY1895344 (A) or MK-1775 with Prexasertib (B). The dash line indicates the predicted combination effect, computed according to the BI method, Eq (3). A) Relative confluence inhibition of BAY1895344 at 166.8 nM combined with MK-1775 at 137.2 nM, with a BI score of 0.42. B) Relative confluence inhibition of prexasertib at 4.7 nM combined with MK-1775 at 137.2 nM, with BI a score of 0.56. (PNG)</p
<p><i>(A and B) Showing isolobolograms analysis of the combination of gemcitabine, Betulinic acid or...
The median-effect principle proposed by Chou and Talalay is the most effective approach to parameter...
(A) The response curves for all 115 combinations (dots) compared to the dose model predictions (soli...
XY- plot and growth rate plot of the best dose-effect combination of MK-1775 with BAY1895344 (A, B) ...
A) Dose-effect combination heatmap over time of a combination range of MK-1775 with a range of prexa...
MK-1775, prexasertib and BAY1895344 dose-response curve analyses, where conventional and GR metrics ...
<p>(A) Isobologram showing effect of fixed ratio combinations of the primary component inhibitor cpd...
<p>When MK-2206 was combined with the mTOR inhibitor rapamycin, synergistic cytotoxicity was observe...
A) A representative checkerboard assay plate, drug concentration is decreased left to right and cisp...
<p>Left hand panels: Growth inhibitory effects of combinations of trametinib with everolimus (TraEvl...
<p>A) AKT inhibitor (green) and TAK1 inhibitor (blue). B) MEK inhibitor (blue) and AKT inhibitor (gr...
<p>Synergy is defined as occurring where the double dose of either of the two individual reagents re...
<p>When MK-2206 was combined with the Mek1/2 inhibitor U0126, synergistic cytotoxicity was observed ...
<p>Growth inhibitory effects of combinations of everolimus with GDC-0941 (GDC) (left hand panel), KU...
<p>Dilution series of the MEK inhibitor AZD-6244 (rows, in nM) and the PI3K inhibitor GDC-0941 (colu...
<p><i>(A and B) Showing isolobolograms analysis of the combination of gemcitabine, Betulinic acid or...
The median-effect principle proposed by Chou and Talalay is the most effective approach to parameter...
(A) The response curves for all 115 combinations (dots) compared to the dose model predictions (soli...
XY- plot and growth rate plot of the best dose-effect combination of MK-1775 with BAY1895344 (A, B) ...
A) Dose-effect combination heatmap over time of a combination range of MK-1775 with a range of prexa...
MK-1775, prexasertib and BAY1895344 dose-response curve analyses, where conventional and GR metrics ...
<p>(A) Isobologram showing effect of fixed ratio combinations of the primary component inhibitor cpd...
<p>When MK-2206 was combined with the mTOR inhibitor rapamycin, synergistic cytotoxicity was observe...
A) A representative checkerboard assay plate, drug concentration is decreased left to right and cisp...
<p>Left hand panels: Growth inhibitory effects of combinations of trametinib with everolimus (TraEvl...
<p>A) AKT inhibitor (green) and TAK1 inhibitor (blue). B) MEK inhibitor (blue) and AKT inhibitor (gr...
<p>Synergy is defined as occurring where the double dose of either of the two individual reagents re...
<p>When MK-2206 was combined with the Mek1/2 inhibitor U0126, synergistic cytotoxicity was observed ...
<p>Growth inhibitory effects of combinations of everolimus with GDC-0941 (GDC) (left hand panel), KU...
<p>Dilution series of the MEK inhibitor AZD-6244 (rows, in nM) and the PI3K inhibitor GDC-0941 (colu...
<p><i>(A and B) Showing isolobolograms analysis of the combination of gemcitabine, Betulinic acid or...
The median-effect principle proposed by Chou and Talalay is the most effective approach to parameter...
(A) The response curves for all 115 combinations (dots) compared to the dose model predictions (soli...