Cell-cell communication result from astrocytes to excitatory neurons and corresponding drug discovering result (mice cohort) using sc2MeNetDrug.

(a) Cell-cell communication result with several important pathways appended. The KEGG database was used and the log-fold-change and p-value threshold are set as 0.08 and 0.05 respectively. (b) Signature drug discovering result. Only top 30 drugs are displayed. The higher the negative enrichment score, the higher chance the drug can be used to inhibit the corresponding dysfunctional network. (c) Drug clustering result based on SMILE finger-print to identify structure similar drug clusters among all top drugs.