Abstract Autosomal dominant pathogenic mutations in Leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease (PD). The most common mutation, G2019S-LRRK2, increases the kinase activity of LRRK2 causing hyper-phosphorylation of its substrates. One of these substrates, Rab10, is phosphorylated at a conserved Thr73 residue (pRab10), and is one of the most abundant LRRK2 Rab GTPases expressed in various tissues. The involvement of Rab10 in neurodegenerative disease, including both PD and Alzheimer’s disease makes pinpointing the cellular and subcellular localization of Rab10 and pRab10 in the brain an important step in understanding its functional role, and how post-translational modifications could impact function. To establish the speci...
The Leucine Rich Repeat Kinase 2 (LRRK2) gene is a major genetic determinant of Parkinson’s disease ...
Genetic variation at the leucine-rich repeat kinase 2 (LRRK2) locus contributes to an enhanced risk ...
Mutations that activate the LRRK2 (leucine-rich repeat protein kinase 2) protein kinase predispose t...
Abstract Background Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of f...
Mutations in LRRK2 cause familial Parkinson's disease and common variants increase disease risk. LRR...
LRRK2 mutations cause Parkinson’s, but the molecular link from increased kinase activity to patholog...
Mutations that activate the LRRK2 (leucine-rich repeat protein kinase 2) protein kinase predispose t...
Autosomal dominant mutations that activate the leucine-rich repeat kinase-2 (LRRK2) cause inherited ...
Activating mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) cause Parkinson's disease. LRRK2 ph...
Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) cause familial Parkinson's disea...
Point mutations in leucine-rich repeat kinase 2 (LRRK2) cause Parkinson's disease and augment LRRK2’...
Mutations in the LRRK2 kinase are the most common cause of familial Parkinson's disease, and variant...
The Leucine Rich Repeat Kinase 2 (LRRK2) gene is a major genetic determinant of Parkinson’s disease ...
Genetic variation at the leucine-rich repeat kinase 2 (LRRK2) locus contributes to an enhanced risk ...
Mutations that activate the LRRK2 (leucine-rich repeat protein kinase 2) protein kinase predispose t...
Abstract Background Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of f...
Mutations in LRRK2 cause familial Parkinson's disease and common variants increase disease risk. LRR...
LRRK2 mutations cause Parkinson’s, but the molecular link from increased kinase activity to patholog...
Mutations that activate the LRRK2 (leucine-rich repeat protein kinase 2) protein kinase predispose t...
Autosomal dominant mutations that activate the leucine-rich repeat kinase-2 (LRRK2) cause inherited ...
Activating mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) cause Parkinson's disease. LRRK2 ph...
Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) cause familial Parkinson's disea...
Point mutations in leucine-rich repeat kinase 2 (LRRK2) cause Parkinson's disease and augment LRRK2’...
Mutations in the LRRK2 kinase are the most common cause of familial Parkinson's disease, and variant...
The Leucine Rich Repeat Kinase 2 (LRRK2) gene is a major genetic determinant of Parkinson’s disease ...
Genetic variation at the leucine-rich repeat kinase 2 (LRRK2) locus contributes to an enhanced risk ...
Mutations that activate the LRRK2 (leucine-rich repeat protein kinase 2) protein kinase predispose t...