Background: Primary hyperparathyroidism (PHPT) affects mainly cortical bone. It is thought that parathyroid hormone (PTH) indirectly regulates the activity of osteoclasts by means of the osteoprotegerin/ligand of the receptor activator of nuclear factor-?? (OPG/RANKL) system. Several studies have confirmed that OPG (osteoprotegerin) and RANKL (ligand of the receptor activator of nuclear factor-??) loci are determinants of bone mineral density (BMD) in the general population. The aim of this study is to analyze the relationship between fractures and BMD and the rs3102735 (163 A/G), rs3134070 (245 T/G) and rs2073618 (1181 G/C) SNPs of the OPG and the rs2277438 SNP of the RANKL, in patients with sporadic PHPT. Methods: We enrolled 298 Caucasi...
Objective: To examine factors, in addition to bone mineral density (BMD), such as the common calcium...
Parathyroid hormone (PTH) is a principal regulator of calcium homeostasis. Previously, we studied si...
Background: Bone mineral density influences the risk of osteoporosis later in life and is useful in ...
Abstract Background Primary hyperparathyroidism (PHPT) affects mainly cortical bone. It is thought t...
Objective: Parathyroid hormone (PTH) and vitamin D are the most important hormones regulating calciu...
INTRODUCTION: Parathyroid hormone (PTH) is a key regulator of calcium metabolism. Parathyroid hormon...
Background: Increased fracture susceptibility is correlated with suboptimal bone quality measures, w...
Purpose: Accumulating evidence implicates parathyroid hormone (PTH) in the development of osteoporos...
We sought to determine the influence of single-nucleotide polymorphisms (SNPs) in RANKL, RANK, and O...
We have investigated the role of 23 candidate genes in the control of bone mineral density (BMD) by ...
The RANKL/RANK/OPG pathway regulates bone remodelling and turnover. However, the genetic background ...
Objective: To examine factors, in addition to bone mineral density (BMD), such as the common calcium...
In order to assess the contribution of polymorphisms in the RANKL (TNFSF11), RANK (TNFRSF11A) and OP...
Abstract Parathyroid glands secrete parathyroid hormone (PTH) which plays multiple roles in calcium ...
We have investigated the role of 23 candidate genes in the control of bone mineral density (BMD) by ...
Objective: To examine factors, in addition to bone mineral density (BMD), such as the common calcium...
Parathyroid hormone (PTH) is a principal regulator of calcium homeostasis. Previously, we studied si...
Background: Bone mineral density influences the risk of osteoporosis later in life and is useful in ...
Abstract Background Primary hyperparathyroidism (PHPT) affects mainly cortical bone. It is thought t...
Objective: Parathyroid hormone (PTH) and vitamin D are the most important hormones regulating calciu...
INTRODUCTION: Parathyroid hormone (PTH) is a key regulator of calcium metabolism. Parathyroid hormon...
Background: Increased fracture susceptibility is correlated with suboptimal bone quality measures, w...
Purpose: Accumulating evidence implicates parathyroid hormone (PTH) in the development of osteoporos...
We sought to determine the influence of single-nucleotide polymorphisms (SNPs) in RANKL, RANK, and O...
We have investigated the role of 23 candidate genes in the control of bone mineral density (BMD) by ...
The RANKL/RANK/OPG pathway regulates bone remodelling and turnover. However, the genetic background ...
Objective: To examine factors, in addition to bone mineral density (BMD), such as the common calcium...
In order to assess the contribution of polymorphisms in the RANKL (TNFSF11), RANK (TNFRSF11A) and OP...
Abstract Parathyroid glands secrete parathyroid hormone (PTH) which plays multiple roles in calcium ...
We have investigated the role of 23 candidate genes in the control of bone mineral density (BMD) by ...
Objective: To examine factors, in addition to bone mineral density (BMD), such as the common calcium...
Parathyroid hormone (PTH) is a principal regulator of calcium homeostasis. Previously, we studied si...
Background: Bone mineral density influences the risk of osteoporosis later in life and is useful in ...