Agonistic and antagonistic drug action

In this article in the series of ‘bite sized’ pharmacology, we will look at the concepts of agonism and antagonism with regards to drug action. These pharmacodynamic actions affect how a drug acts at its target site and the body's response to the drug. Knowledge of agonism and antagonism can assist the prescriber in drug choice. Knowing where a drug works, whether it is an agonist or antagonist and whether any other drugs have the same or opposing actions at that site of action is a crucial part of safe prescribing practice. It also helps the prescriber understand why some drugs cannot be prescribed in combination