Inhibition of neddylation represses lipopolysaccharide-induced proinflammatory cytokine production in macrophage cells
- Chang, Fang-Mei
- Reyna, Sara M.
- Granados, Jose C.
- Wei, Sung-Jen
- Innis-Whitehouse, Wendy
- Maffi, Shivani K.
- Rodriguez, Edward
- Slaga, Thomas J.
- Short, John D.
Publication date
October 2012
DOI Publisher
ScholarWorks @ UTRGV Language
EnglishAbstract
Background: Lipopolysaccharides (LPSs) up-regulate proinflammatory cytokines in macrophages, partly through a NF-κB-dependent process. Results: Blocking neddylation, which helps regulate NF-κB, represses LPS-induced up-regulation of proinflammatory cytokines. Conclusion: Neddylation plays a role in the up-regulation of NF-κB-regulated proinflammatory cytokines produced by macrophages in response to LPS. Significance: Inhibition of neddylation represents a novel and effective method for the prevention of LPS-induced proinflammatory cytokines
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