A novel class of benzimidazole-thiazole products have been designed as potential inhibitors of cyclooxygenase, and the synthesized compound structures were verified using instrumental analysis techniques. The in vitro inhibitory effect on COX-1 was dose-dependent, with a significant reduction in effectiveness at lower concentrations. Among the compounds (7b) (IC50 0.297 μM) (7c) (IC50 0.311 μM) (8b) (IC50 0.279 μM) and (8c) (IC50 0.215 μM), which are the most active compounds, IC50 values were close to celecoxib (IC50 0.132 μM) against COX-2. Molecular docking studies were carried out on compounds against COX-2 using Glide XP. The compounds 7b, 7c, 8b, and 8c demonstrated significant docking scores of −8.927 kcal mol−1, −8.578 kcal mol−1, −...
Series of diaryl-based pyrazole and triazole derivatives were designed and synthesized in a facile s...
In an attempt to identify potential COX-2 inhibitors, a multi-step virtual screening strategy was pe...
Non-steroidal anti-inflammatory drugs are inhibitors of cyclooxygenase-2 (COX-2) that were developed...
A group of cyclic imides (1-13) was designed for evaluation as selective COX-2 inhibitors and invest...
Cyclooxygenase (COX) is a key enzyme in the biosynthetic pathway leading to the formation of prostag...
In an attempt to identify potential COX-2 inhibitors, a multi-step virtual screening strategy was pe...
Comparative molecular field analysis and comparative molecular similarity indices analysis were perf...
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used therapeutic agents that exhibit fre...
The overexpression of cyclooxygenase-2 (COX-2) was clearly associated with carcinogenesis, and COX-2...
Heterocyclic compounds with diaryl substituents have been a milestone approach for selective cycloox...
Non-steroidal anti-inflammatory drugs are inhibitors of cyclooxygenase-2 (COX-2) that were developed...
The recent discovery of a second, inducible isoform of cyclooxygenase, COX-2, has stimulated the sea...
A novel series of 12 antipyrine derivatives containing 1,3,4-oxadiazoles (4a-d), 1,3,4-thiadiazoles ...
AbstractNew series of 3,4-diaryl-2-thioxoimidazolidin-4-ones and 3-alkylthio-4,5-diaryl-4H-1,2,4-tri...
A new class of cox-2 inhibitors of novel 2 phenyl 3 substituted aniline derivatives were synthesized...
Series of diaryl-based pyrazole and triazole derivatives were designed and synthesized in a facile s...
In an attempt to identify potential COX-2 inhibitors, a multi-step virtual screening strategy was pe...
Non-steroidal anti-inflammatory drugs are inhibitors of cyclooxygenase-2 (COX-2) that were developed...
A group of cyclic imides (1-13) was designed for evaluation as selective COX-2 inhibitors and invest...
Cyclooxygenase (COX) is a key enzyme in the biosynthetic pathway leading to the formation of prostag...
In an attempt to identify potential COX-2 inhibitors, a multi-step virtual screening strategy was pe...
Comparative molecular field analysis and comparative molecular similarity indices analysis were perf...
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used therapeutic agents that exhibit fre...
The overexpression of cyclooxygenase-2 (COX-2) was clearly associated with carcinogenesis, and COX-2...
Heterocyclic compounds with diaryl substituents have been a milestone approach for selective cycloox...
Non-steroidal anti-inflammatory drugs are inhibitors of cyclooxygenase-2 (COX-2) that were developed...
The recent discovery of a second, inducible isoform of cyclooxygenase, COX-2, has stimulated the sea...
A novel series of 12 antipyrine derivatives containing 1,3,4-oxadiazoles (4a-d), 1,3,4-thiadiazoles ...
AbstractNew series of 3,4-diaryl-2-thioxoimidazolidin-4-ones and 3-alkylthio-4,5-diaryl-4H-1,2,4-tri...
A new class of cox-2 inhibitors of novel 2 phenyl 3 substituted aniline derivatives were synthesized...
Series of diaryl-based pyrazole and triazole derivatives were designed and synthesized in a facile s...
In an attempt to identify potential COX-2 inhibitors, a multi-step virtual screening strategy was pe...
Non-steroidal anti-inflammatory drugs are inhibitors of cyclooxygenase-2 (COX-2) that were developed...