This paper considers the estimation of a semi-parametric single-index regression model that allows for nonlinear predictive relationships. This model is useful for predicting financial asset returns, whose observed behaviour resembles a stationary process, if the multiple nonstationary predictors are cointegrated. The presence of cointegrated regressors imposes a single-index structure in the model, and this structure not only balances the nonstationarity properties of the multiple predictors with the stationarity properties of asset returns but also avoids the curse of dimensionality associated with nonparametric regression function estimation. An orthogonal series expansion is used to approximate the unknown link function for the single-i...