DataSheet_1_The HLA-B*57:01 allele corresponds to a very large MHC haploblock likely explaining its massive effect for HIV-1 elite control.docx

Myriam Rahmouni (12282827)
Lorenzo De Marco (17613798)
Jean-Louis Spadoni (76756)
Maxime Tison (17613801)
Raissa Medina-Santos (17613804)
Taoufik Labib (795186)
Josselin Noirel (87373)
Ryad Tamouza (705838)
Sophie Limou (214649)
Olivier Delaneau (76754)
Jacques Fellay (192975)
Armand Bensussan (214677)
Sigrid Le Clerc (269086)
Paul J. McLaren (13876463)
Jean-François Zagury (76757)

Publication date

December 2023

DOI

10.3389/fimmu.2023.1305856.s001

Abstract

IntroductionWe have reanalyzed the genomic data of the International Collaboration for the Genomics of HIV (ICGH), centering on HIV-1 Elite Controllers.MethodsWe performed a genome-wide Association Study comparing 543 HIV Elite Controllers with 3,272 uninfected controls of European descent. Using the latest database for imputation, we analyzed 35,552 Single Nucleotide Polymorphisms (SNPs) within the Major Histocompatibility Complex (MHC) region.ResultsOur analysis identified 2,626 SNPs significantly associated (pDiscussionThese findings suggest that additional molecular mechanisms beyond the conventional antigen-presenting role of class I HLA molecules may contribute to the observed influence of HLA-B*57:01/B*57:03 alleles on HIV-1 elite co...

Extracted data

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DataSheet_1_The HLA-B*57:01 allele corresponds to a very large MHC haploblock likely explaining its massive effect for HIV-1 elite control.docx

Myriam Rahmouni (12282827)
Lorenzo De Marco (17613798)
Jean-Louis Spadoni (76756)
Maxime Tison (17613801)
Raissa Medina-Santos (17613804)
Taoufik Labib (795186)
Josselin Noirel (87373)
Ryad Tamouza (705838)
Sophie Limou (214649)
Olivier Delaneau (76754)
Jacques Fellay (192975)
Armand Bensussan (214677)
Sigrid Le Clerc (269086)
Paul J. McLaren (13876463)
Jean-François Zagury (76757)

Open link

Publication date

December 2023

DOI

10.3389/fimmu.2023.1305856.s001

Abstract

Extracted data

McLaren, P.J.
Coulonges, C.
Bartha, I.
Lenz, T.L.
Deutsch, A.J.
Bashirova, A.
Buchbinder, S.
Carrington, M.N.
Cossarizza, A.
Dalmau, J.
De Luca, A.
Goedert, J.J.
Gurdasani, D.
Haas, D.W.
Herbeck, J.T.
Johnson, E.O.
Kirk, G.D.
Lambotte, O.
Luo, M.
Mallal, S.
van Manen, D.
Martinez-Picado, J.
Meyer, L.
Miro, J.M.
Mullins, J.I.
Obel, N.
Poli, G.
Sandhu, M.S.
Schuitemaker, H.
Shea, P.R.
Theodorou, I.
Walker, B.D.
Weintrob, A.C.
Winkler, C.A.
Wolinsky, S.M.
Raychaudhuri, S.
Goldstein, D.B.
Telenti, A.
de Bakker, P.I.W.
Zagury, J-F
Fellay, J.

January 2015

Previous genome-wide association studies (GWAS) of HIV-1–infected populations have been underpowered...

Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study.

Cyril Dalmasso
Wassila Carpentier
Laurence Meyer
Christine Rouzioux
Cécile Goujard
Marie-Laure Chaix
Olivier Lambotte
Véronique Avettand-Fenoel
Sigrid Le Clerc
Laure Denis de Senneville
Christiane Deveau
Faroudy Boufassa
Patrice Debré
Jean-François Delfraissy
Philippe Broet
Ioannis Theodorou

Previous studies of the HIV-1 disease have shown that HLA and Chemokine receptor genetic variants in...

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

Pereyra, F.
Jia, X.
McLaren, P.J.
Telenti, A.
de Bakker, P.I.W.
Walker, B.D.
Ripke, S.
Brumme, C.J.
Pulit, S.L.
Carrington, M.
Kadie, C.M.
Carlson, J.M.
Heckerman, D.
Graham, R.R.
Plenge, R.M.
Deeks, S.G.
Gianniny, L.
Crawford, G.
Sullivan, J.
Gonzalez, E.
Davies, L.
Camargo, A.
Moore, J.M
Beattie, N.
Gupta, S.
Crenshaw, A.
Burtt, N.P.
Guiducci, C.
Gupta, N.
Gao, X.
Qi, Y.
Yuki, Y.
Piechocka-Trocha, A.
Cutrell, E.
Rosenberg, R.
Moss, K.L.
Lemay, P.
O'Leary, J.
Schaefer, T.
Verma, P.
Tóth, I.
Block, B.
Baker, B.
Rothchild, A.
Lian, J.
Proudfoot, J.
Alvino, D.M.L.
Vine, S.
Addo, M.M.
Allen, T.M.
Altfeld, M.
Henn, M.R.
Le Gall, S.
Streeck, H.
Haas, D.W.
Kuritzkes, D.R.
Robbins, G.K.
Shafer, R.W.
Gulick, R.M.
Shikuma, C.M.
Haubrich, R.
Riddler, S.
Sax, P.E.
Daar, E.S.
Ribaudo, H.J.
Agan, B.
Agarwal, S.
Ahern, R.L.
Allen, B.L.
Altidor, S.
Altschuler, E.L.
Ambardar, S.
Anastos, K.
Anderson, B.
Anderson, V.
Andrady, U.
Antoniskis, D.
Bangsberg, D.
Barbaro, D.
Barrie, W.
Bartczak, J.
Barton, S.
Basden, P.
Basgoz, N.
Bazner, S.
Bellos, N.C.
Benson, A.M.
Berger, J.
Bernard, N.F.
Bernard, A.M.
Birch, C.
Bodner, S.J.
Bolan, R.K.
Boudreaux, E.T.
Bradley, M.
Braun, J.F.
Brndjar, J.E.
Brown, S.J.
Brown, K.
Brown, S.T.
Burack, J.
Bush, L.M.
Cafaro, V.
Campbell, O.
Campbell, J.
Carlson, R.H.
Carmichael, J.K.
Casey, K.K.
Cavacuiti, C.
Celestin, G.
Chambers, S.T.
Chez, N.
Chirch, L.M.
Cimoch, P.J.
Cohen, D.
Cohn, L.E.
Conway, B.
Cooper, D.A.
Cornelson, B.
Cox, D.T.
Cristofano, M.V.
Cuchural, G.
Czartoski, J.L.
Dahman, J.M.
Daly, J.S.
Davis, B.T.
Davis, K.
Davod, S.M.
DeJesus, E.
Dietz, C.A.
Dunham, E.
Dunn, M.E.
Ellerin, T.B.
Eron, J.J.
Fangman, J.J.W.
Farel, C.E.
Ferlazzo, H.
Fidler, S.
Fleenor-Ford, A.
Frankel, R.
Freedberg, K.A.
French, N.K.
Fuchs, J.D.
Fuller, J.D.
Gaberman, J.
Gallant, J.E.
Gandhi, R.T.
García, E.
Garmon, D.
Gathe, J.C.
Gaultier, C.R.
Gebre, W.
Gilman, F.D.
Gilson, I.
Goepfert, P.A.
Gottlieb, M.S.
Goulston, C.
Groger, R.K.
Gurley, T.D.
Haber, S.
Hardwicke, R.
Hardy, W.D.
Harrigan, P.R.
Hawkins, T.N.
Heath, S.
Hecht, F.M.
Henry, W.K.
Hladek, M.
Hoffman, R.P.
Horton, J.M.
Hsu, R.K.
Huhn, G.D.
Hunt, P.
Hupert, M.J.
Illeman, M.L.
Jaeger, H.
Jellinger, R.M.
John, M.
Johnson, J.A.
Johnson, K.L.
Johnson, H.
Johnson, K.
Joly, J.
Jordan, W.C.
Kauffman, C.A.
Khanlou, H.
Killian, R.K.
Kim, A.Y.
Kim, D.D.
Kinder, C.A.
Kirchner, J.T.
Kogelman, L.
Kojic, E.M.
Korthuis, P.T.
Kurisu, W.
Kwon, D.S.
LaMar, M.
Lampiris, H.
Lanzafame, M.
Lederman, M.M.
Lee, D.M.
Lee, J.M.L.
Lee, M.J.
Lee, E.T.Y.
Lemoine, J.
Levy, J.A.
Llibre, J.M.
Liguori, M.A.
Little, S.J.
Liu, A.Y.
Lopez, A.J.
Loutfy, M.R.
Loy, D.
Mohammed, D.Y.
Man, A.
Mansour, M.K.
Marconi, V.C.
Markowitz, M.
Marques, R.
Martin, J.N.
Martin, H.L.
Mayer, K.H.
McElrath, M.J.
McGhee, T.A.
McGovern, B.H.
McGowan, K.
McIntyre, D.
Mcleod, G.X.
Menezes, P.
Mesa, G.
Metroka, C.E.
Meyer-Olson, D.
Miller, A.O.
Montgomery, K.
Mounzer, K.C.
Nagami, E.H.
Nagin, I.
Nahass, R.G.
Nelson, M.O.
Nielsen, C.
Norene, D.L.
O'Connor, D.H.
Ojikutu, B.O.
Okulicz, J.
Oladehin, O.O.
Oldfield, E.C.
Olender, S.A.
Ostrowski, M.
Owen, W.F.
Pae, E.
Parsonnet, J.
Pavlatos, A.M.
Perlmutter, A.M.
Pierce, M.N.
Pincus, J.M.
Pisani, L.
Price, L.J.
Proia, L.
Prokesch, R.C.
Pujet, H.C.
Ramgopal, M.
Rathod, A.
Rausch, M.
Ravishankar, J.
Rhame, F.S.
Richards, C.S.
Richman, D.D.
Rodes, B.
Rodriguez, M.
Rose, R.C.
Rosenberg, E.S.
Rosenthal, D.
Ross, P.E.
Rubin, D.S.
Rumbaugh, E.
Saenz, L.
Salvaggio, M.R.
Sanchez, W.C.
Sanjana, V.M.
Santiago, S.
Schmidt, W.
Schuitemaker, H.
Sestak, P.M.
Shalit, P.
Shay, W.
Shirvani, V.N.
Silebi, V.I.
Sizemore, J.M.
Skolnik, P.R.
Sokol-Anderson, M.
Sosman, J.M.
Stabile, P.
Stapleton, J.T.
Starrett, S.
Stein, F.
Stellbrink, H-J
Sterman, F.L.
Stone, V.E.
Stone, D.R.
Tambussi, G.
Taplitz, R.A.
Tedaldi, E.M.
Telenti, A.
Theisen, W.
Torres, R.
Tosiello, L.
Tremblay, C.
Tribble, M.A.
Trinh, P.D.
Tsao, A.
Ueda, P.
Vaccaro, A.
Valadas, E.
Vanig, T.J.
Vecino, I.
Vega, V.M.
Veikley, W.
Wade, B.H.
Walworth, C.
Wanidworanun, C.
Ward, D.J.
Warner, D.A.
Weber, R.D.
Webster, D.
Weis, S.
Wheeler, D.A.
White, D.J.
Wilkins, E.
Winston, A.
Wlodaver, C.G.
van't Wout, A.
Wright, D.P.
Yang, O.O.
Yurdin, D.L.
Zabukovic, B.W.
Zachary, K.C.
Zeeman, B.
Zhao, M.

December 2010

Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the ma...

Image_1_The HLA-B*57:01 allele corresponds to a very large MHC haploblock likely explaining its massive effect for HIV-1 elite control.jpeg

Myriam Rahmouni (12282827)
Lorenzo De Marco (17613798)
Jean-Louis Spadoni (76756)
Maxime Tison (17613801)
Raissa Medina-Santos (17613804)
Taoufik Labib (795186)
Josselin Noirel (87373)
Ryad Tamouza (705838)
Sophie Limou (214649)
Olivier Delaneau (76754)
Jacques Fellay (192975)
Armand Bensussan (214677)
Sigrid Le Clerc (269086)
Paul J. McLaren (13876463)
Jean-François Zagury (76757)

December 2023

IntroductionWe have reanalyzed the genomic data of the International Collaboration for the Genomics ...

Table_1_The HLA-B*57:01 allele corresponds to a very large MHC haploblock likely explaining its massive effect for HIV-1 elite control.xlsx

Myriam Rahmouni (12282827)
Lorenzo De Marco (17613798)
Jean-Louis Spadoni (76756)
Maxime Tison (17613801)
Raissa Medina-Santos (17613804)
Taoufik Labib (795186)
Josselin Noirel (87373)
Ryad Tamouza (705838)
Sophie Limou (214649)
Olivier Delaneau (76754)
Jacques Fellay (192975)
Armand Bensussan (214677)
Sigrid Le Clerc (269086)
Paul J. McLaren (13876463)
Jean-François Zagury (76757)

December 2023

IntroductionWe have reanalyzed the genomic data of the International Collaboration for the Genomics ...

Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection Open Access

Sagar A Vaidya
Hendrik Streeck
Noor Beckwith
Musie Ghebremichael
Florencia Pereyra
Douglas S Kwon
Marylyn M Addo
Jenna Rychert
Jean-pierre Routy
Heiko Jessen
Anthony D Kelleher
Eric S Rosenberg
Marcus Altfeld

September 2014

Background: HLA-B alleles are associated with viral control in chronic HIV-1 infection, however, the...

Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans

McLaren, P.J.
Ripke, S.
Pelak, K.
Weintrob, A.C.
Patsopoulos, N.A.
Jia, X.
Erlich, R.L.
Lennon, N.J.
Kadie, C.M.
Heckerman, D.
Gupta, N.
Haas, D.W.
Deeks, S.G.
Pereyra, F.
Walker, B.D.
de Bakker, P.I.W.
John, M.

January 2012

A small proportion of human immunodeficiency virus-1 (HIV-1) infected individuals, termed HIV-1 cont...

Common DNA variants within the MHC region that are associated with HIV-1 acquisition comparing 6,334 HIV-1 infected patients to 7,247 population controls are driven by HIV-1 controllers and not maintained when restricting to patients with known dates of seroconversion.

Paul J. McLaren (151463)
Cédric Coulonges (76755)
Stephan Ripke (156076)
Leonard van den Berg (437389)
Susan Buchbinder (31646)
Mary Carrington (64679)
Andrea Cossarizza (295123)
Judith Dalmau (180283)
Steven G. Deeks (131630)
Olivier Delaneau (76754)
Andrea De Luca (132288)
James J. Goedert (199127)
David Haas (437390)
Joshua T. Herbeck (214670)
Sekar Kathiresan (60585)
Gregory D. Kirk (199129)
Olivier Lambotte (252533)
Ma Luo (153573)
Simon Mallal (75844)
Daniëlle van Manen (85698)
Javier Martinez-Picado (91236)
Laurence Meyer (130347)
José M. Miro (255427)
James I. Mullins (30582)
Niels Obel (135891)
Stephen J. O'Brien (53045)
Florencia Pereyra (178819)
Francis A. Plummer (149579)
Guido Poli (164113)
Ying Qi (59980)
Pierre Rucart (437391)
Manj S. Sandhu (200068)
Patrick R. Shea (437392)
Hanneke Schuitemaker (85702)
Ioannis Theodorou (157932)
Fredrik Vannberg (437393)
Jan Veldink (187567)
Bruce D. Walker (64224)
Amy Weintrob (299466)
Cheryl A. Winkler (115868)
Steven Wolinsky (437394)
Amalio Telenti (25361)
David B. Goldstein (194563)
Paul I. W. de Bakker (61332)
Jean-François Zagury (76757)
Jacques Fellay (192975)

July 2013

<p>A) Regional association plot of the locus containing genome-wide significant SNPs after meta-anal...

Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection

Vaidya, Sagar A
Streeck, Hendrik
Beckwith, Noor
Ghebremichael, Musie
Pereyra, Florencia
Kwon, Douglas S
Addo, Marylyn M
Rychert, Jenna
Routy, Jean-Pierre
Jessen, Heiko
Kelleher, Anthony D
Hecht, Frederick
Sekaly, Rafick-Pierre
Carrington, Mary
Walker, Bruce D
Allen, Todd M
Rosenberg, Eric S
Altfeld, Marcus

November 2013

Abstract Background HLA-B alleles are associated with viral control in chronic HIV-1 infection, howe...

HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles.

Gabriel Catano
Hemant Kulkarni
Weijing He
Vincent C Marconi
Brian K Agan
Michael Landrum
Stephanie Anderson
Judith Delmar
Vanessa Telles
Li Song
John Castiblanco
Robert A Clark
Matthew J Dolan
Sunil K Ahuja

A recent genome-wide association study (GWAS) suggested that polymorphisms in or around the genes HC...

Distinct Genetic Loci Control Plasma HIV-RNA and Cellular HIV-DNA Levels in HIV-1 Infection: The ANRS Genome Wide Association 01 Study

Dalmasso, Cyril
Carpentier, Wassila
Meyer, Laurence
Rouzioux, Christine
Goujard, Cécile
Chaix, Marie-Laure
Lambotte, Olivier
Avettand-Fenoël, Véronique
Le Clerc, Sigrid
de Senneville, Laure Denis
Deveau, Christiane
Boufassa, Faroudy
Debré, Patrice
Delfraissy, Jean-François
Broët, Philippe
Theodorou, Ioannis

January 2008

International audiencePrevious studies of the HIV-1 disease have shown that HLA and Chemokine recept...

Genomewide Association Study of an AIDS‐Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02)

Limou, Sophie
Le Clerc, Sigrid
Coulonges, Cédric
Carpentier, Wassila
Dina, Christian
Delaneau, Olivier
Labib, Taoufik
Taing, Lieng
Sladek, Rob
Deveau, Christiane
Ratsimandresy, Rojo
Montes, Matthieu
Spadoni, Jean-Louis
Lelièvre, Jean-Daniel
Levy, Yves
Therwath, Amu
Schächter, François
Matsuda, Fumihiko
Gut, Ivo
Froguel, Philippe
Delfraissy, Jean-François
Hercberg, Serge
Zagury, Jean-François

February 2009

To elucidate the genetic factors predisposing to AIDS progression, we analyzed a unique cohort of 27...

Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load

McLaren, P.J.
Coulonges, C.
Bartha, I.
Lenz, T.L.
Deutsch, A.J.
Bashirova, A.
Buchbinder, S.
Carrington, M.N.
Cossarizza, A.
Dalmau, J.
De Luca, A.
Goedert, J.J.
Gurdasani, D.
Haas, D.W.
Herbeck, J.T.
Johnson, E.O.
Kirk, G.D.
Lambotte, O.
Luo, M.
Mallal, S.
van Manen, D.
Martinez-Picado, J.
Meyer, L.
Miro, J.M.
Mullins, J.I.
Obel, N.
Poli, G.
Sandhu, M.S.
Schuitemaker, H.
Shea, P.R.
Theodorou, I.
Walker, B.D.
Weintrob, A.C.
Winkler, C.A.
Wolinsky, S.M.
Raychaudhuri, S.
Goldstein, D.B.
Telenti, A.
de Bakker, P.I.W.
Zagury, J-F
Fellay, J.

January 2015

Previous genome-wide association studies (GWAS) of HIV-1–infected populations have been underpowered...

Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study.

Cyril Dalmasso
Wassila Carpentier
Laurence Meyer
Christine Rouzioux
Cécile Goujard
Marie-Laure Chaix
Olivier Lambotte
Véronique Avettand-Fenoel
Sigrid Le Clerc
Laure Denis de Senneville
Christiane Deveau
Faroudy Boufassa
Patrice Debré
Jean-François Delfraissy
Philippe Broet
Ioannis Theodorou

Previous studies of the HIV-1 disease have shown that HLA and Chemokine receptor genetic variants in...

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

Pereyra, F.
Jia, X.
McLaren, P.J.
Telenti, A.
de Bakker, P.I.W.
Walker, B.D.
Ripke, S.
Brumme, C.J.
Pulit, S.L.
Carrington, M.
Kadie, C.M.
Carlson, J.M.
Heckerman, D.
Graham, R.R.
Plenge, R.M.
Deeks, S.G.
Gianniny, L.
Crawford, G.
Sullivan, J.
Gonzalez, E.
Davies, L.
Camargo, A.
Moore, J.M
Beattie, N.
Gupta, S.
Crenshaw, A.
Burtt, N.P.
Guiducci, C.
Gupta, N.
Gao, X.
Qi, Y.
Yuki, Y.
Piechocka-Trocha, A.
Cutrell, E.
Rosenberg, R.
Moss, K.L.
Lemay, P.
O'Leary, J.
Schaefer, T.
Verma, P.
Tóth, I.
Block, B.
Baker, B.
Rothchild, A.
Lian, J.
Proudfoot, J.
Alvino, D.M.L.
Vine, S.
Addo, M.M.
Allen, T.M.
Altfeld, M.
Henn, M.R.
Le Gall, S.
Streeck, H.
Haas, D.W.
Kuritzkes, D.R.
Robbins, G.K.
Shafer, R.W.
Gulick, R.M.
Shikuma, C.M.
Haubrich, R.
Riddler, S.
Sax, P.E.
Daar, E.S.
Ribaudo, H.J.
Agan, B.
Agarwal, S.
Ahern, R.L.
Allen, B.L.
Altidor, S.
Altschuler, E.L.
Ambardar, S.
Anastos, K.
Anderson, B.
Anderson, V.
Andrady, U.
Antoniskis, D.
Bangsberg, D.
Barbaro, D.
Barrie, W.
Bartczak, J.
Barton, S.
Basden, P.
Basgoz, N.
Bazner, S.
Bellos, N.C.
Benson, A.M.
Berger, J.
Bernard, N.F.
Bernard, A.M.
Birch, C.
Bodner, S.J.
Bolan, R.K.
Boudreaux, E.T.
Bradley, M.
Braun, J.F.
Brndjar, J.E.
Brown, S.J.
Brown, K.
Brown, S.T.
Burack, J.
Bush, L.M.
Cafaro, V.
Campbell, O.
Campbell, J.
Carlson, R.H.
Carmichael, J.K.
Casey, K.K.
Cavacuiti, C.
Celestin, G.
Chambers, S.T.
Chez, N.
Chirch, L.M.
Cimoch, P.J.
Cohen, D.
Cohn, L.E.
Conway, B.
Cooper, D.A.
Cornelson, B.
Cox, D.T.
Cristofano, M.V.
Cuchural, G.
Czartoski, J.L.
Dahman, J.M.
Daly, J.S.
Davis, B.T.
Davis, K.
Davod, S.M.
DeJesus, E.
Dietz, C.A.
Dunham, E.
Dunn, M.E.
Ellerin, T.B.
Eron, J.J.
Fangman, J.J.W.
Farel, C.E.
Ferlazzo, H.
Fidler, S.
Fleenor-Ford, A.
Frankel, R.
Freedberg, K.A.
French, N.K.
Fuchs, J.D.
Fuller, J.D.
Gaberman, J.
Gallant, J.E.
Gandhi, R.T.
García, E.
Garmon, D.
Gathe, J.C.
Gaultier, C.R.
Gebre, W.
Gilman, F.D.
Gilson, I.
Goepfert, P.A.
Gottlieb, M.S.
Goulston, C.
Groger, R.K.
Gurley, T.D.
Haber, S.
Hardwicke, R.
Hardy, W.D.
Harrigan, P.R.
Hawkins, T.N.
Heath, S.
Hecht, F.M.
Henry, W.K.
Hladek, M.
Hoffman, R.P.
Horton, J.M.
Hsu, R.K.
Huhn, G.D.
Hunt, P.
Hupert, M.J.
Illeman, M.L.
Jaeger, H.
Jellinger, R.M.
John, M.
Johnson, J.A.
Johnson, K.L.
Johnson, H.
Johnson, K.
Joly, J.
Jordan, W.C.
Kauffman, C.A.
Khanlou, H.
Killian, R.K.
Kim, A.Y.
Kim, D.D.
Kinder, C.A.
Kirchner, J.T.
Kogelman, L.
Kojic, E.M.
Korthuis, P.T.
Kurisu, W.
Kwon, D.S.
LaMar, M.
Lampiris, H.
Lanzafame, M.
Lederman, M.M.
Lee, D.M.
Lee, J.M.L.
Lee, M.J.
Lee, E.T.Y.
Lemoine, J.
Levy, J.A.
Llibre, J.M.
Liguori, M.A.
Little, S.J.
Liu, A.Y.
Lopez, A.J.
Loutfy, M.R.
Loy, D.
Mohammed, D.Y.
Man, A.
Mansour, M.K.
Marconi, V.C.
Markowitz, M.
Marques, R.
Martin, J.N.
Martin, H.L.
Mayer, K.H.
McElrath, M.J.
McGhee, T.A.
McGovern, B.H.
McGowan, K.
McIntyre, D.
Mcleod, G.X.
Menezes, P.
Mesa, G.
Metroka, C.E.
Meyer-Olson, D.
Miller, A.O.
Montgomery, K.
Mounzer, K.C.
Nagami, E.H.
Nagin, I.
Nahass, R.G.
Nelson, M.O.
Nielsen, C.
Norene, D.L.
O'Connor, D.H.
Ojikutu, B.O.
Okulicz, J.
Oladehin, O.O.
Oldfield, E.C.
Olender, S.A.
Ostrowski, M.
Owen, W.F.
Pae, E.
Parsonnet, J.
Pavlatos, A.M.
Perlmutter, A.M.
Pierce, M.N.
Pincus, J.M.
Pisani, L.
Price, L.J.
Proia, L.
Prokesch, R.C.
Pujet, H.C.
Ramgopal, M.
Rathod, A.
Rausch, M.
Ravishankar, J.
Rhame, F.S.
Richards, C.S.
Richman, D.D.
Rodes, B.
Rodriguez, M.
Rose, R.C.
Rosenberg, E.S.
Rosenthal, D.
Ross, P.E.
Rubin, D.S.
Rumbaugh, E.
Saenz, L.
Salvaggio, M.R.
Sanchez, W.C.
Sanjana, V.M.
Santiago, S.
Schmidt, W.
Schuitemaker, H.
Sestak, P.M.
Shalit, P.
Shay, W.
Shirvani, V.N.
Silebi, V.I.
Sizemore, J.M.
Skolnik, P.R.
Sokol-Anderson, M.
Sosman, J.M.
Stabile, P.
Stapleton, J.T.
Starrett, S.
Stein, F.
Stellbrink, H-J
Sterman, F.L.
Stone, V.E.
Stone, D.R.
Tambussi, G.
Taplitz, R.A.
Tedaldi, E.M.
Telenti, A.
Theisen, W.
Torres, R.
Tosiello, L.
Tremblay, C.
Tribble, M.A.
Trinh, P.D.
Tsao, A.
Ueda, P.
Vaccaro, A.
Valadas, E.
Vanig, T.J.
Vecino, I.
Vega, V.M.
Veikley, W.
Wade, B.H.
Walworth, C.
Wanidworanun, C.
Ward, D.J.
Warner, D.A.
Weber, R.D.
Webster, D.
Weis, S.
Wheeler, D.A.
White, D.J.
Wilkins, E.
Winston, A.
Wlodaver, C.G.
van't Wout, A.
Wright, D.P.
Yang, O.O.
Yurdin, D.L.
Zabukovic, B.W.
Zachary, K.C.
Zeeman, B.
Zhao, M.

December 2010

Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the ma...

Image_1_The HLA-B*57:01 allele corresponds to a very large MHC haploblock likely explaining its massive effect for HIV-1 elite control.jpeg

Myriam Rahmouni (12282827)
Lorenzo De Marco (17613798)
Jean-Louis Spadoni (76756)
Maxime Tison (17613801)
Raissa Medina-Santos (17613804)
Taoufik Labib (795186)
Josselin Noirel (87373)
Ryad Tamouza (705838)
Sophie Limou (214649)
Olivier Delaneau (76754)
Jacques Fellay (192975)
Armand Bensussan (214677)
Sigrid Le Clerc (269086)
Paul J. McLaren (13876463)
Jean-François Zagury (76757)

December 2023

IntroductionWe have reanalyzed the genomic data of the International Collaboration for the Genomics ...

Table_1_The HLA-B*57:01 allele corresponds to a very large MHC haploblock likely explaining its massive effect for HIV-1 elite control.xlsx

Myriam Rahmouni (12282827)
Lorenzo De Marco (17613798)
Jean-Louis Spadoni (76756)
Maxime Tison (17613801)
Raissa Medina-Santos (17613804)
Taoufik Labib (795186)
Josselin Noirel (87373)
Ryad Tamouza (705838)
Sophie Limou (214649)
Olivier Delaneau (76754)
Jacques Fellay (192975)
Armand Bensussan (214677)
Sigrid Le Clerc (269086)
Paul J. McLaren (13876463)
Jean-François Zagury (76757)

December 2023

IntroductionWe have reanalyzed the genomic data of the International Collaboration for the Genomics ...

Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection Open Access

Sagar A Vaidya
Hendrik Streeck
Noor Beckwith
Musie Ghebremichael
Florencia Pereyra
Douglas S Kwon
Marylyn M Addo
Jenna Rychert
Jean-pierre Routy
Heiko Jessen
Anthony D Kelleher
Eric S Rosenberg
Marcus Altfeld

September 2014

Background: HLA-B alleles are associated with viral control in chronic HIV-1 infection, however, the...

Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans

McLaren, P.J.
Ripke, S.
Pelak, K.
Weintrob, A.C.
Patsopoulos, N.A.
Jia, X.
Erlich, R.L.
Lennon, N.J.
Kadie, C.M.
Heckerman, D.
Gupta, N.
Haas, D.W.
Deeks, S.G.
Pereyra, F.
Walker, B.D.
de Bakker, P.I.W.
John, M.

January 2012

A small proportion of human immunodeficiency virus-1 (HIV-1) infected individuals, termed HIV-1 cont...

Paul J. McLaren (151463)
Cédric Coulonges (76755)
Stephan Ripke (156076)
Leonard van den Berg (437389)
Susan Buchbinder (31646)
Mary Carrington (64679)
Andrea Cossarizza (295123)
Judith Dalmau (180283)
Steven G. Deeks (131630)
Olivier Delaneau (76754)
Andrea De Luca (132288)
James J. Goedert (199127)
David Haas (437390)
Joshua T. Herbeck (214670)
Sekar Kathiresan (60585)
Gregory D. Kirk (199129)
Olivier Lambotte (252533)
Ma Luo (153573)
Simon Mallal (75844)
Daniëlle van Manen (85698)
Javier Martinez-Picado (91236)
Laurence Meyer (130347)
José M. Miro (255427)
James I. Mullins (30582)
Niels Obel (135891)
Stephen J. O'Brien (53045)
Florencia Pereyra (178819)
Francis A. Plummer (149579)
Guido Poli (164113)
Ying Qi (59980)
Pierre Rucart (437391)
Manj S. Sandhu (200068)
Patrick R. Shea (437392)
Hanneke Schuitemaker (85702)
Ioannis Theodorou (157932)
Fredrik Vannberg (437393)
Jan Veldink (187567)
Bruce D. Walker (64224)
Amy Weintrob (299466)
Cheryl A. Winkler (115868)
Steven Wolinsky (437394)
Amalio Telenti (25361)
David B. Goldstein (194563)
Paul I. W. de Bakker (61332)
Jean-François Zagury (76757)
Jacques Fellay (192975)

July 2013

<p>A) Regional association plot of the locus containing genome-wide significant SNPs after meta-anal...

Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection

Vaidya, Sagar A
Streeck, Hendrik
Beckwith, Noor
Ghebremichael, Musie
Pereyra, Florencia
Kwon, Douglas S
Addo, Marylyn M
Rychert, Jenna
Routy, Jean-Pierre
Jessen, Heiko
Kelleher, Anthony D
Hecht, Frederick
Sekaly, Rafick-Pierre
Carrington, Mary
Walker, Bruce D
Allen, Todd M
Rosenberg, Eric S
Altfeld, Marcus

November 2013

Abstract Background HLA-B alleles are associated with viral control in chronic HIV-1 infection, howe...

HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles.

Gabriel Catano
Hemant Kulkarni
Weijing He
Vincent C Marconi
Brian K Agan
Michael Landrum
Stephanie Anderson
Judith Delmar
Vanessa Telles
Li Song
John Castiblanco
Robert A Clark
Matthew J Dolan
Sunil K Ahuja

A recent genome-wide association study (GWAS) suggested that polymorphisms in or around the genes HC...

Distinct Genetic Loci Control Plasma HIV-RNA and Cellular HIV-DNA Levels in HIV-1 Infection: The ANRS Genome Wide Association 01 Study

Dalmasso, Cyril
Carpentier, Wassila
Meyer, Laurence
Rouzioux, Christine
Goujard, Cécile
Chaix, Marie-Laure
Lambotte, Olivier
Avettand-Fenoël, Véronique
Le Clerc, Sigrid
de Senneville, Laure Denis
Deveau, Christiane
Boufassa, Faroudy
Debré, Patrice
Delfraissy, Jean-François
Broët, Philippe
Theodorou, Ioannis

January 2008

International audiencePrevious studies of the HIV-1 disease have shown that HLA and Chemokine recept...

Genomewide Association Study of an AIDS‐Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02)

Limou, Sophie
Le Clerc, Sigrid
Coulonges, Cédric
Carpentier, Wassila
Dina, Christian
Delaneau, Olivier
Labib, Taoufik
Taing, Lieng
Sladek, Rob
Deveau, Christiane
Ratsimandresy, Rojo
Montes, Matthieu
Spadoni, Jean-Louis
Lelièvre, Jean-Daniel
Levy, Yves
Therwath, Amu
Schächter, François
Matsuda, Fumihiko
Gut, Ivo
Froguel, Philippe
Delfraissy, Jean-François
Hercberg, Serge
Zagury, Jean-François

February 2009

To elucidate the genetic factors predisposing to AIDS progression, we analyzed a unique cohort of 27...

Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load

McLaren, P.J.
Coulonges, C.
Bartha, I.
Lenz, T.L.
Deutsch, A.J.
Bashirova, A.
Buchbinder, S.
Carrington, M.N.
Cossarizza, A.
Dalmau, J.
De Luca, A.
Goedert, J.J.
Gurdasani, D.
Haas, D.W.
Herbeck, J.T.
Johnson, E.O.
Kirk, G.D.
Lambotte, O.
Luo, M.
Mallal, S.
van Manen, D.
Martinez-Picado, J.
Meyer, L.
Miro, J.M.
Mullins, J.I.
Obel, N.
Poli, G.
Sandhu, M.S.
Schuitemaker, H.
Shea, P.R.
Theodorou, I.
Walker, B.D.
Weintrob, A.C.
Winkler, C.A.
Wolinsky, S.M.
Raychaudhuri, S.
Goldstein, D.B.
Telenti, A.
de Bakker, P.I.W.
Zagury, J-F
Fellay, J.

January 2015

Previous genome-wide association studies (GWAS) of HIV-1–infected populations have been underpowered...

Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study.

Cyril Dalmasso
Wassila Carpentier
Laurence Meyer
Christine Rouzioux
Cécile Goujard
Marie-Laure Chaix
Olivier Lambotte
Véronique Avettand-Fenoel
Sigrid Le Clerc
Laure Denis de Senneville
Christiane Deveau
Faroudy Boufassa
Patrice Debré
Jean-François Delfraissy
Philippe Broet
Ioannis Theodorou

Previous studies of the HIV-1 disease have shown that HLA and Chemokine receptor genetic variants in...

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

Pereyra, F.
Jia, X.
McLaren, P.J.
Telenti, A.
de Bakker, P.I.W.
Walker, B.D.
Ripke, S.
Brumme, C.J.
Pulit, S.L.
Carrington, M.
Kadie, C.M.
Carlson, J.M.
Heckerman, D.
Graham, R.R.
Plenge, R.M.
Deeks, S.G.
Gianniny, L.
Crawford, G.
Sullivan, J.
Gonzalez, E.
Davies, L.
Camargo, A.
Moore, J.M
Beattie, N.
Gupta, S.
Crenshaw, A.
Burtt, N.P.
Guiducci, C.
Gupta, N.
Gao, X.
Qi, Y.
Yuki, Y.
Piechocka-Trocha, A.
Cutrell, E.
Rosenberg, R.
Moss, K.L.
Lemay, P.
O'Leary, J.
Schaefer, T.
Verma, P.
Tóth, I.
Block, B.
Baker, B.
Rothchild, A.
Lian, J.
Proudfoot, J.
Alvino, D.M.L.
Vine, S.
Addo, M.M.
Allen, T.M.
Altfeld, M.
Henn, M.R.
Le Gall, S.
Streeck, H.
Haas, D.W.
Kuritzkes, D.R.
Robbins, G.K.
Shafer, R.W.
Gulick, R.M.
Shikuma, C.M.
Haubrich, R.
Riddler, S.
Sax, P.E.
Daar, E.S.
Ribaudo, H.J.
Agan, B.
Agarwal, S.
Ahern, R.L.
Allen, B.L.
Altidor, S.
Altschuler, E.L.
Ambardar, S.
Anastos, K.
Anderson, B.
Anderson, V.
Andrady, U.
Antoniskis, D.
Bangsberg, D.
Barbaro, D.
Barrie, W.
Bartczak, J.
Barton, S.
Basden, P.
Basgoz, N.
Bazner, S.
Bellos, N.C.
Benson, A.M.
Berger, J.
Bernard, N.F.
Bernard, A.M.
Birch, C.
Bodner, S.J.
Bolan, R.K.
Boudreaux, E.T.
Bradley, M.
Braun, J.F.
Brndjar, J.E.
Brown, S.J.
Brown, K.
Brown, S.T.
Burack, J.
Bush, L.M.
Cafaro, V.
Campbell, O.
Campbell, J.
Carlson, R.H.
Carmichael, J.K.
Casey, K.K.
Cavacuiti, C.
Celestin, G.
Chambers, S.T.
Chez, N.
Chirch, L.M.
Cimoch, P.J.
Cohen, D.
Cohn, L.E.
Conway, B.
Cooper, D.A.
Cornelson, B.
Cox, D.T.
Cristofano, M.V.
Cuchural, G.
Czartoski, J.L.
Dahman, J.M.
Daly, J.S.
Davis, B.T.
Davis, K.
Davod, S.M.
DeJesus, E.
Dietz, C.A.
Dunham, E.
Dunn, M.E.
Ellerin, T.B.
Eron, J.J.
Fangman, J.J.W.
Farel, C.E.
Ferlazzo, H.
Fidler, S.
Fleenor-Ford, A.
Frankel, R.
Freedberg, K.A.
French, N.K.
Fuchs, J.D.
Fuller, J.D.
Gaberman, J.
Gallant, J.E.
Gandhi, R.T.
García, E.
Garmon, D.
Gathe, J.C.
Gaultier, C.R.
Gebre, W.
Gilman, F.D.
Gilson, I.
Goepfert, P.A.
Gottlieb, M.S.
Goulston, C.
Groger, R.K.
Gurley, T.D.
Haber, S.
Hardwicke, R.
Hardy, W.D.
Harrigan, P.R.
Hawkins, T.N.
Heath, S.
Hecht, F.M.
Henry, W.K.
Hladek, M.
Hoffman, R.P.
Horton, J.M.
Hsu, R.K.
Huhn, G.D.
Hunt, P.
Hupert, M.J.
Illeman, M.L.
Jaeger, H.
Jellinger, R.M.
John, M.
Johnson, J.A.
Johnson, K.L.
Johnson, H.
Johnson, K.
Joly, J.
Jordan, W.C.
Kauffman, C.A.
Khanlou, H.
Killian, R.K.
Kim, A.Y.
Kim, D.D.
Kinder, C.A.
Kirchner, J.T.
Kogelman, L.
Kojic, E.M.
Korthuis, P.T.
Kurisu, W.
Kwon, D.S.
LaMar, M.
Lampiris, H.
Lanzafame, M.
Lederman, M.M.
Lee, D.M.
Lee, J.M.L.
Lee, M.J.
Lee, E.T.Y.
Lemoine, J.
Levy, J.A.
Llibre, J.M.
Liguori, M.A.
Little, S.J.
Liu, A.Y.
Lopez, A.J.
Loutfy, M.R.
Loy, D.
Mohammed, D.Y.
Man, A.
Mansour, M.K.
Marconi, V.C.
Markowitz, M.
Marques, R.
Martin, J.N.
Martin, H.L.
Mayer, K.H.
McElrath, M.J.
McGhee, T.A.
McGovern, B.H.
McGowan, K.
McIntyre, D.
Mcleod, G.X.
Menezes, P.
Mesa, G.
Metroka, C.E.
Meyer-Olson, D.
Miller, A.O.
Montgomery, K.
Mounzer, K.C.
Nagami, E.H.
Nagin, I.
Nahass, R.G.
Nelson, M.O.
Nielsen, C.
Norene, D.L.
O'Connor, D.H.
Ojikutu, B.O.
Okulicz, J.
Oladehin, O.O.
Oldfield, E.C.
Olender, S.A.
Ostrowski, M.
Owen, W.F.
Pae, E.
Parsonnet, J.
Pavlatos, A.M.
Perlmutter, A.M.
Pierce, M.N.
Pincus, J.M.
Pisani, L.
Price, L.J.
Proia, L.
Prokesch, R.C.
Pujet, H.C.
Ramgopal, M.
Rathod, A.
Rausch, M.
Ravishankar, J.
Rhame, F.S.
Richards, C.S.
Richman, D.D.
Rodes, B.
Rodriguez, M.
Rose, R.C.
Rosenberg, E.S.
Rosenthal, D.
Ross, P.E.
Rubin, D.S.
Rumbaugh, E.
Saenz, L.
Salvaggio, M.R.
Sanchez, W.C.
Sanjana, V.M.
Santiago, S.
Schmidt, W.
Schuitemaker, H.
Sestak, P.M.
Shalit, P.
Shay, W.
Shirvani, V.N.
Silebi, V.I.
Sizemore, J.M.
Skolnik, P.R.
Sokol-Anderson, M.
Sosman, J.M.
Stabile, P.
Stapleton, J.T.
Starrett, S.
Stein, F.
Stellbrink, H-J
Sterman, F.L.
Stone, V.E.
Stone, D.R.
Tambussi, G.
Taplitz, R.A.
Tedaldi, E.M.
Telenti, A.
Theisen, W.
Torres, R.
Tosiello, L.
Tremblay, C.
Tribble, M.A.
Trinh, P.D.
Tsao, A.
Ueda, P.
Vaccaro, A.
Valadas, E.
Vanig, T.J.
Vecino, I.
Vega, V.M.
Veikley, W.
Wade, B.H.
Walworth, C.
Wanidworanun, C.
Ward, D.J.
Warner, D.A.
Weber, R.D.
Webster, D.
Weis, S.
Wheeler, D.A.
White, D.J.
Wilkins, E.
Winston, A.
Wlodaver, C.G.
van't Wout, A.
Wright, D.P.
Yang, O.O.
Yurdin, D.L.
Zabukovic, B.W.
Zachary, K.C.
Zeeman, B.
Zhao, M.

December 2010

Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the ma...

DataSheet_1_The HLA-B*57:01 allele corresponds to a very large MHC haploblock likely explaining its massive effect for HIV-1 elite control.docx

Abstract

Extracted data

DataSheet_1_The HLA-B*57:01 allele corresponds to a very large MHC haploblock likely explaining its massive effect for HIV-1 elite control.docx

Abstract

Extracted data

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