Host STAT6 immunity affects N. brasiliensis gene expression of common families. A-B. Selected top up- and downregulated gene family terms identified in gene set enrichment analysis (GSEA), of WT- or STAT6 KO-derived adult day 7 female worms, from an infection with (A) parental N. brasiliensis stock, G1, or (B) WT (generation 15) or STAT6 KO (generation 14) adapted N. brasiliensis stock.</p
STAT6 KO-adapted N. brasiliensis elicit a stronger inflammatory WT host immune response. Mesenteric ...
Modulation of immune responses to helminth infections by concurrent protozoan pathogens has been sho...
A. Survival curve with average host survival by days post infection for WT hosts infected with WT-ad...
G14 STAT6 KO-adapted N. brasiliensis down-regulate gene categories associated with ESPs. A-B. Heatma...
N. brasiliensis has an altered transcriptional profile within STAT6 KO hosts. A. Experimental design...
Heatmaps of gene sets of interest from A. Day 5 females WT versus STAT6 KO hosts infected with proge...
A. Experimental evolution design, N. brasiliensis (originally isolated from rat host, brown) were in...
STAT6 KO-adapted N. brasiliensis do not exhibit attenuation of fitness when challenged within WT mic...
A. Venn diagrams of significantly up (Log2FoldChange > 2) versus down (Log2FoldChange B. Scatterplot...
The impact of the host immune environment on parasite transcription and fitness is currently unknown...
Graphical summary. WT-adapted hookworms within WT host environment (upper left box) have impeded sur...
Mesenteric lymph node data (A-J) A. Experimental design; Parental worms infected WT or STAT6 KO mice...
A. 10x magnification images of adult female WT or STAT6 KO-adapted worms (generation 23 and 22) deri...
Supernatant from 3-day cultures of WT or STAT6 KO- adapted (G24/23) N. brasiliensis was used to stim...
Summary of regression analysis of host immune cell populations versus hookworm adaptation genotypes,...
STAT6 KO-adapted N. brasiliensis elicit a stronger inflammatory WT host immune response. Mesenteric ...
Modulation of immune responses to helminth infections by concurrent protozoan pathogens has been sho...
A. Survival curve with average host survival by days post infection for WT hosts infected with WT-ad...
G14 STAT6 KO-adapted N. brasiliensis down-regulate gene categories associated with ESPs. A-B. Heatma...
N. brasiliensis has an altered transcriptional profile within STAT6 KO hosts. A. Experimental design...
Heatmaps of gene sets of interest from A. Day 5 females WT versus STAT6 KO hosts infected with proge...
A. Experimental evolution design, N. brasiliensis (originally isolated from rat host, brown) were in...
STAT6 KO-adapted N. brasiliensis do not exhibit attenuation of fitness when challenged within WT mic...
A. Venn diagrams of significantly up (Log2FoldChange > 2) versus down (Log2FoldChange B. Scatterplot...
The impact of the host immune environment on parasite transcription and fitness is currently unknown...
Graphical summary. WT-adapted hookworms within WT host environment (upper left box) have impeded sur...
Mesenteric lymph node data (A-J) A. Experimental design; Parental worms infected WT or STAT6 KO mice...
A. 10x magnification images of adult female WT or STAT6 KO-adapted worms (generation 23 and 22) deri...
Supernatant from 3-day cultures of WT or STAT6 KO- adapted (G24/23) N. brasiliensis was used to stim...
Summary of regression analysis of host immune cell populations versus hookworm adaptation genotypes,...
STAT6 KO-adapted N. brasiliensis elicit a stronger inflammatory WT host immune response. Mesenteric ...
Modulation of immune responses to helminth infections by concurrent protozoan pathogens has been sho...
A. Survival curve with average host survival by days post infection for WT hosts infected with WT-ad...