G14 STAT6 KO-adapted N. brasiliensis down-regulate gene categories associated with ESPs. A-B. Heatmap and GSEA enrichment plot of transcripts encoding gene categories associated with ESPs for WT or STAT6 KO generation 15/14 adapted female N. brasiliensis derived from passage host at day 7 post infection. C-F. Heatmap or GSEA enrichment plot of transcripts encoding adult stage ESP-associated gene categories for G1 N. brasiliensis infection of WT or STAT6 KO mice, (C-D) of day 5 post infection female worms or (E-F) day 7 post infection female worms.</p
(A) Heatmap of 32 genes related to DNA replication that were downregulated in treated females. Genes...
Mesenteric lymph node data (A-J) A. Experimental design; Parental worms infected WT or STAT6 KO mice...
A. Survival curve with average host survival by days post infection for WT hosts infected with WT-ad...
N. brasiliensis has an altered transcriptional profile within STAT6 KO hosts. A. Experimental design...
Host STAT6 immunity affects N. brasiliensis gene expression of common families. A-B. Selected top up...
Heatmaps of gene sets of interest from A. Day 5 females WT versus STAT6 KO hosts infected with proge...
STAT6 KO-adapted N. brasiliensis do not exhibit attenuation of fitness when challenged within WT mic...
A. Heatmap and GSEA enrichment plot for genes encoding adult stage ESP-associated gene categories. B...
A. PCA plot. B. Hierarchical clustering. C. Volcano plot of differential gene expression results; si...
A. Venn diagrams of significantly up (Log2FoldChange > 2) versus down (Log2FoldChange B. Scatterplot...
(A) Heatmap of 51 genes related to ncRNA metabolism that were downregulated in treated females. The ...
A. Experimental evolution design, N. brasiliensis (originally isolated from rat host, brown) were in...
A-C. Plots of eggs per gram of feces (EPG) by days post infection of WT mice infected with STAT6 KO-...
Summary of regression analysis of host immune cell populations versus hookworm adaptation genotypes,...
The impact of the host immune environment on parasite transcription and fitness is currently unknown...
(A) Heatmap of 32 genes related to DNA replication that were downregulated in treated females. Genes...
Mesenteric lymph node data (A-J) A. Experimental design; Parental worms infected WT or STAT6 KO mice...
A. Survival curve with average host survival by days post infection for WT hosts infected with WT-ad...
N. brasiliensis has an altered transcriptional profile within STAT6 KO hosts. A. Experimental design...
Host STAT6 immunity affects N. brasiliensis gene expression of common families. A-B. Selected top up...
Heatmaps of gene sets of interest from A. Day 5 females WT versus STAT6 KO hosts infected with proge...
STAT6 KO-adapted N. brasiliensis do not exhibit attenuation of fitness when challenged within WT mic...
A. Heatmap and GSEA enrichment plot for genes encoding adult stage ESP-associated gene categories. B...
A. PCA plot. B. Hierarchical clustering. C. Volcano plot of differential gene expression results; si...
A. Venn diagrams of significantly up (Log2FoldChange > 2) versus down (Log2FoldChange B. Scatterplot...
(A) Heatmap of 51 genes related to ncRNA metabolism that were downregulated in treated females. The ...
A. Experimental evolution design, N. brasiliensis (originally isolated from rat host, brown) were in...
A-C. Plots of eggs per gram of feces (EPG) by days post infection of WT mice infected with STAT6 KO-...
Summary of regression analysis of host immune cell populations versus hookworm adaptation genotypes,...
The impact of the host immune environment on parasite transcription and fitness is currently unknown...
(A) Heatmap of 32 genes related to DNA replication that were downregulated in treated females. Genes...
Mesenteric lymph node data (A-J) A. Experimental design; Parental worms infected WT or STAT6 KO mice...
A. Survival curve with average host survival by days post infection for WT hosts infected with WT-ad...