(a) The experimental abundance levels (solid line) and degradation rates (open circles) of the mouse PERIOD2 (PER2) protein [43]. (b) The experimental abundance levels (dots, interpolated by a solid line) and degradation rates (open circles) of PSEUDO RESPONSE REGULATOR 7 (PRR7) protein in Arabidopsis thaliana [44,45,48]. Horizontal white and black segments correspond to light and dark intervals, respectively. (c) A simulated protein degradation rate from the full kinetic model and its ETS- and QSSA-based estimates, when the degradation depends on a single PTM. In addition, the protein abundance profile is presented here (gray solid line). A vertical dashed line corresponds to the peak time of −A′(t)/A(t) where A(t) is a protein abundance. ...
We assess the accuracy of various state-of-the-art statistics and machine learning methods for recon...
<p>A and B, Temporal expression profiles of <i>Angptl2</i> mRNA in epididymal WAT of mice housed und...
The rich mammalian cellular circadian output affects thousands of genes in many cell types and has b...
<p>Upper panel: R protein degradation rate (and other parameters as described in the text) with the...
Circadian protein oscillations are maintained by the lifelong repetition of protein production and d...
Summary: Circadian protein oscillations are maintained by the lifelong repetition of protein product...
<p>(A) Heat maps of circadian rhythmic proteins ordered by the phase of maximal expression as in <a ...
(A), (B) Schematic representation of the degradation and induction responses of the circadian clock....
<p>The R protein degradation rate with the dynamics calculated with the stochastic algorithm. The r...
SummaryThe rich mammalian cellular circadian output affects thousands of genes in many cell types an...
<p>(A) Schematic representation of the workflow followed to perform the quantitative proteomics anal...
The amount of cellular proteins is a crucial parameter that is known to vary between cells as a func...
The rich mammalian cellular circadian output affects thousands of genes in many cell types and has b...
Protein turnover is a key aspect of cellular homeostasis and proteome dynamics. However, there is li...
<p>(<b>a</b>)–(<b>c</b>) Comparison of group-averaged cumulative distributions of rescaled resting ...
We assess the accuracy of various state-of-the-art statistics and machine learning methods for recon...
<p>A and B, Temporal expression profiles of <i>Angptl2</i> mRNA in epididymal WAT of mice housed und...
The rich mammalian cellular circadian output affects thousands of genes in many cell types and has b...
<p>Upper panel: R protein degradation rate (and other parameters as described in the text) with the...
Circadian protein oscillations are maintained by the lifelong repetition of protein production and d...
Summary: Circadian protein oscillations are maintained by the lifelong repetition of protein product...
<p>(A) Heat maps of circadian rhythmic proteins ordered by the phase of maximal expression as in <a ...
(A), (B) Schematic representation of the degradation and induction responses of the circadian clock....
<p>The R protein degradation rate with the dynamics calculated with the stochastic algorithm. The r...
SummaryThe rich mammalian cellular circadian output affects thousands of genes in many cell types an...
<p>(A) Schematic representation of the workflow followed to perform the quantitative proteomics anal...
The amount of cellular proteins is a crucial parameter that is known to vary between cells as a func...
The rich mammalian cellular circadian output affects thousands of genes in many cell types and has b...
Protein turnover is a key aspect of cellular homeostasis and proteome dynamics. However, there is li...
<p>(<b>a</b>)–(<b>c</b>) Comparison of group-averaged cumulative distributions of rescaled resting ...
We assess the accuracy of various state-of-the-art statistics and machine learning methods for recon...
<p>A and B, Temporal expression profiles of <i>Angptl2</i> mRNA in epididymal WAT of mice housed und...
The rich mammalian cellular circadian output affects thousands of genes in many cell types and has b...