Adverse Effect after Radiation Therapy

Introduction: The objective of the study is to evaluate and analyze acute and late toxicity of GU genito-urinary tract, estimating GFR as a marker of kidney function, and investigate adverse effect of treatment accordingRTOG scoring system at the at 3-rd and 6-th month of treatment. Material and methods: This study is done at Clinical Center of Kosovo, Oncology Department. 75 patients are evaluated where several variables have been investigated: sex, age, type of primary malignancy, Median TD (tumor dose) evidence over 50 and above 50 Gy. At the beginning, at 3rd and 6th of the treatment patient have been followed by fulfilling in the questioner according RTOG scoring system. Chemotherapy have been employed based on primary tumor site concurrently with radiotherapi Median follow up (FU) have take 6 months. Excluding criteria: Patients with PGUM (Pre Treatment GenitoUrinary Morbidity). G0 of RTOG score at the beginning of treatment to all patients. Results: Our cohort consist of 75 patients with pelvic tumors of which 53 or 70.7% were female and 22 or 29.3% of male. The average age of the patients involved in the research was 57.5 years (SD ± 11.2 years) range 33-77 years. The average age of the female patients involved in the research was 56.1 years (DS ±11.1 years), range 33 – 77 years. The average age of the male patients involved in the research was 60.8 years (SD ±11.1years), range 37 – 74 years. Females are with 3 various types of carcinomas (cervical and endometrial) and males with only 1 (rectal). The 75 patients involved in the research 30 or 40.0% were rectal carcinomas, 28 or 37.3% were cervical carcinomas and 17 or 22.7% were endometrial carcinomas. Conclusions: No significant differences in treatment related site effects between radiotherapy and hemoradiation groups were found. In the follow up after 3 months from 75 patients involved in the research, 11 patients (14.7 %) had G1 GU toxicity that did not need any kind of treatment. 5 patients (6.7%) had G2 GU toxicity. Whereas in the follow up after 6 months 15 patients (20%) had G1 GU toxicity, 7 patients (9.3%) G2 GU toxicity and 4 patients (5.3%) had G3 GU toxicity. Compering grade of toxicity between follow up 3 and 6 months no significant differences have been appeared according RT treatment.Keywords: Urinary toxicity, adverse effects RTOG, pelvic radiotherapy