There is growing evidence that oxidative stress plays a role in melasma and disrupts primary cilia formation. Additionally, primary cilia have been suggested to have an inhibitory role in melanogenesis. This study examined the potential link between oxidative stress, skin hyperpigmentation, and primary cilia. We compared the expression levels of the nuclear factor E2-related factor 2 (NRF2), intraflagellar transport 88 (IFT88), and glioma-associated oncogene homologs (GLIs) in skin samples from patients with melasma, both in affected and unaffected areas. We also explored the roles of NRF2, IFT88, and GLIs in ciliogenesis and pigmentation using cultured adult human keratinocytes, with or without melanocytes. Our findings revealed decreased ...
Epidermal melanocytes are particularly vulnerable to oxidative stress owing to the pro-oxidant state...
Oxidative stress due to increased epidermal levels of H(2)O(2) with consequent inhibition of catalas...
Vitiligo is characterized by the progressive disappearance of pigment cells from skin and hair folli...
The primary cilium is an organelle protruding from the cell body that senses external stimuli includ...
Vitiligo melanocytes possess higher susceptibility to oxidative insults. Consistent with this, impai...
Nrf2 plays a role in protection of cells against oxidative stress and xenobiotic damage by regulatin...
<div><p>Nrf2 plays a role in protection of cells against oxidative stress and xenobiotic damage by r...
We have recently reported a potential alternative tumor suppressor function for p16 relating to its ...
Oxidative stress is widely believed to be a contributing factor in vitiligo pathogenesis. To explore...
Oxidative stress caused by hydrogen peroxide (H2O2) leads to cell death and has been implicated in t...
Oxidative stress is widely believed to be a contributing factor in vitiligo pathogenesis. To explore...
The transcription factor NRF2 is the major mediator of oxidative stress responses and is closely con...
<p>Melan-a cells were transfected with scrambled control (siNC) or GLI2 siRNA. After 24 h, the cells...
The skin is constantly exposed to exogenous and endogenous sources of reactive oxygen species (ROS)....
Particulate matter (PM) is believed to be related to cardiovascular and respiratory diseases. The sk...
Epidermal melanocytes are particularly vulnerable to oxidative stress owing to the pro-oxidant state...
Oxidative stress due to increased epidermal levels of H(2)O(2) with consequent inhibition of catalas...
Vitiligo is characterized by the progressive disappearance of pigment cells from skin and hair folli...
The primary cilium is an organelle protruding from the cell body that senses external stimuli includ...
Vitiligo melanocytes possess higher susceptibility to oxidative insults. Consistent with this, impai...
Nrf2 plays a role in protection of cells against oxidative stress and xenobiotic damage by regulatin...
<div><p>Nrf2 plays a role in protection of cells against oxidative stress and xenobiotic damage by r...
We have recently reported a potential alternative tumor suppressor function for p16 relating to its ...
Oxidative stress is widely believed to be a contributing factor in vitiligo pathogenesis. To explore...
Oxidative stress caused by hydrogen peroxide (H2O2) leads to cell death and has been implicated in t...
Oxidative stress is widely believed to be a contributing factor in vitiligo pathogenesis. To explore...
The transcription factor NRF2 is the major mediator of oxidative stress responses and is closely con...
<p>Melan-a cells were transfected with scrambled control (siNC) or GLI2 siRNA. After 24 h, the cells...
The skin is constantly exposed to exogenous and endogenous sources of reactive oxygen species (ROS)....
Particulate matter (PM) is believed to be related to cardiovascular and respiratory diseases. The sk...
Epidermal melanocytes are particularly vulnerable to oxidative stress owing to the pro-oxidant state...
Oxidative stress due to increased epidermal levels of H(2)O(2) with consequent inhibition of catalas...
Vitiligo is characterized by the progressive disappearance of pigment cells from skin and hair folli...