Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells.
- Nigam, S
- Burke, BP
- Davies, LH
- Domarkas, J
- Wallis, JF
- Waddell, PG
- Waby, J
- Benoit, DM
- Seymour, AM
- Cawthorne, C
- Higham, LJ
- Archibald, SJ
DOI Publisher
Royal Society of Chemistry (RSC)Abstract
The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored and are the first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed
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