Novel 3-(1H-indol-3-yl)-1,2,4-oxadiazoles and -thiadiazoles were synthesized and found to be potent CB1 cannabinoid receptor agonists. The oral bioavailability of these compounds could be dramatically improved by optimization studies of the side chains attached to the indole and oxadiazole cores, leading to identification of a CB1 receptor agonist with good oral activity in a range of preclinical models of antinociception and antihyperalgesia
In this work, the synthesis of the cannabinoid receptor 1 neutral antagonists 8-chloro-1-(2,4-dichlo...
The discovery, synthesis and preliminary structure-activity relationships (SARs) of a novel class of...
Recent data indicated that the CB,, cannabinoid receptor constitutes an attractive drug target due t...
Novel 3-(1H-indol-3-yl)-1,2,4-oxadiazoles and -thiadiazoles were synthesized and found to be potent ...
An exploratory chemical effort has been undertaken to develop a novel series of compounds as selecti...
The CB1 cannabinoid receptor is a widely distributed G-protein coupled receptor in human central and...
The discovery, synthesis and structure-activity relationship (SAR) of a novel series of cannabinoid ...
[[abstract]]Based on the bioisosteric replacement of the pyrazole C3-carboxamide of rimonabant with ...
In our search for new cannabinoid receptor modulators, we describe herein the design and synthesis o...
Selectively targeting the cannabinoid receptor CB2 is an attractive therapeutic strategy for the tre...
In our search for new cannabinoid receptor modulators, we describe herein the design and synthesis o...
Cannabinoid (CB) receptors are validated drug targets in the endocannabinoid signaling system associ...
Synthesis of an antagonist, SR141716A, that selectively binds to brain cannabinoid (CB1) receptors w...
In our search for new cannabinoid receptors modulators, we describe herein the design and synthesis ...
In this work, the synthesis of the cannabinoid receptor 1 neutral antagonists 8-chloro-1-(2,4-dichlo...
In this work, the synthesis of the cannabinoid receptor 1 neutral antagonists 8-chloro-1-(2,4-dichlo...
The discovery, synthesis and preliminary structure-activity relationships (SARs) of a novel class of...
Recent data indicated that the CB,, cannabinoid receptor constitutes an attractive drug target due t...
Novel 3-(1H-indol-3-yl)-1,2,4-oxadiazoles and -thiadiazoles were synthesized and found to be potent ...
An exploratory chemical effort has been undertaken to develop a novel series of compounds as selecti...
The CB1 cannabinoid receptor is a widely distributed G-protein coupled receptor in human central and...
The discovery, synthesis and structure-activity relationship (SAR) of a novel series of cannabinoid ...
[[abstract]]Based on the bioisosteric replacement of the pyrazole C3-carboxamide of rimonabant with ...
In our search for new cannabinoid receptor modulators, we describe herein the design and synthesis o...
Selectively targeting the cannabinoid receptor CB2 is an attractive therapeutic strategy for the tre...
In our search for new cannabinoid receptor modulators, we describe herein the design and synthesis o...
Cannabinoid (CB) receptors are validated drug targets in the endocannabinoid signaling system associ...
Synthesis of an antagonist, SR141716A, that selectively binds to brain cannabinoid (CB1) receptors w...
In our search for new cannabinoid receptors modulators, we describe herein the design and synthesis ...
In this work, the synthesis of the cannabinoid receptor 1 neutral antagonists 8-chloro-1-(2,4-dichlo...
In this work, the synthesis of the cannabinoid receptor 1 neutral antagonists 8-chloro-1-(2,4-dichlo...
The discovery, synthesis and preliminary structure-activity relationships (SARs) of a novel class of...
Recent data indicated that the CB,, cannabinoid receptor constitutes an attractive drug target due t...